Head and Neck

Mucoepidermoid carcinoma of the parotid gland treated by surgery and postoperative radiation therapy: Clinicopathologic correlates of outcome

Corresponding Author

Allen M. Chen MD

Department of Radiation Oncology, University of California, Davis School of Medicine, Sacramento, California, U.S.A

Send correspondence to Allen M. Chen, MD, Department of Radiation Oncology, University of California, Davis Comprehensive Cancer Center, Sacramento, CA 95817. E-mail: [email protected]Search for more papers by this author

Valerie H. Lau BS,

Valerie H. Lau BS

Department of Radiation Oncology, University of California, Davis School of Medicine, Sacramento, California, U.S.A

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D. Gregory Farwell MD,

D. Gregory Farwell MD

Department of Otolaryngology–Head and Neck Surgery, University of California, Davis School of Medicine, Sacramento, California, U.S.A

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Quang Luu MD,

Quang Luu MD

Department of Otolaryngology–Head and Neck Surgery, University of California, Davis School of Medicine, Sacramento, California, U.S.A

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Paul J. Donald MD,

Paul J. Donald MD

Department of Otolaryngology–Head and Neck Surgery, University of California, Davis School of Medicine, Sacramento, California, U.S.A

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Allen M. Chen MD,

Corresponding Author

Allen M. Chen MD

Department of Radiation Oncology, University of California, Davis School of Medicine, Sacramento, California, U.S.A

Valerie H. Lau BS,

Valerie H. Lau BS

Department of Radiation Oncology, University of California, Davis School of Medicine, Sacramento, California, U.S.A

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D. Gregory Farwell MD,

D. Gregory Farwell MD

Department of Otolaryngology–Head and Neck Surgery, University of California, Davis School of Medicine, Sacramento, California, U.S.A

Search for more papers by this author

Quang Luu MD,

Quang Luu MD

Department of Otolaryngology–Head and Neck Surgery, University of California, Davis School of Medicine, Sacramento, California, U.S.A

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Paul J. Donald MD,

Paul J. Donald MD

Department of Otolaryngology–Head and Neck Surgery, University of California, Davis School of Medicine, Sacramento, California, U.S.A

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First published: 11 June 2013

https://doi.org/10.1002/lary.24238

Citations: 49

The authors have no funding, financial relationships, or conflicts of interest to disclose.

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Abstract

Objectives/Hypothesis

To determine clinical and pathological correlates of outcome among patients treated by surgery and postoperative radiation therapy for mucoepidermoid carcinoma of the parotid gland.

Study Design

Retrospective review.

Methods

The medical records of 61 patients treated by surgery and postoperative radiation therapy for localized mucoepidermoid carcinoma of the parotid gland were retrospectively reviewed in an attempt to identify clinicopathologic correlates of overall survival. Secondary endpoints included local-regional control, distant metastasis-free survival, and complications.

Results

The 3- and 5-year estimates of overall survival were 85% and 79%, respectively. Multivariate analysis identified high tumor grade (hazard ratio [HR] = 7.92) and T4 disease (HR = 3.35) as independent predictors of decreased survival, with the former also predicting for distant metastasis and the latter predicting for local-regional recurrence. The 5-year estimate of overall survival was 83% for patients with non-high-grade tumors, compared to 52% for those with high-grade histology (P = 0.001). Late complications included trismus (2 patients), osteoradionecrosis (1 patient), and hearing loss (1 patient).

Conclusion

Patients with high-grade tumors and T4 disease are at increased risk for treatment failure after surgery and postoperative radiation therapy for mucoepidermoid carcinoma of the parotid gland. Investigative strategies to improve outcome should be considered for these particular patients in the future.

Level of Evidence

4. Laryngoscope, 123:3049–3055, 2013

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Citing Literature

Volume123, Issue12

December 2013

Pages 3049-3055

Mucoepidermoid carcinoma of the parotid gland treated by surgery and postoperative radiation therapy: Clinicopathologic correlates of outcome

Abstract

Objectives/Hypothesis

Study Design

Methods

Results

Conclusion

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

Information

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Mucoepidermoid carcinoma of the parotid gland treated by surgery and postoperative radiation therapy: Clinicopathologic correlates of outcome

Abstract

Objectives/Hypothesis

Study Design

Methods

Results

Conclusion

Level of Evidence

BIBLIOGRAPHY

Citing Literature

References

Related

Information