Benign salivary gland tumors: A cytogenetic study of 21 cases
Carmo Martins BSc
Departmento de Patologia Morfológica and Centro de Investigação de Patobiologia Molecular, Instituto Portuguěs de Oncologia de Francisco Gentil, Lisbon, Portugal
Search for more papers by this authorIsabel Fonseca MD, PhD
Departmento de Patologia Morfológica and Centro de Investigação de Patobiologia Molecular, Instituto Portuguěs de Oncologia de Francisco Gentil, Lisbon, Portugal
Search for more papers by this authorAna Félix MD
Departmento de Patologia Morfológica and Centro de Investigação de Patobiologia Molecular, Instituto Portuguěs de Oncologia de Francisco Gentil, Lisbon, Portugal
Search for more papers by this authorLúcia Roque BSc
Departmento de Patologia Morfológica and Centro de Investigação de Patobiologia Molecular, Instituto Portuguěs de Oncologia de Francisco Gentil, Lisbon, Portugal
Search for more papers by this authorCorresponding Author
Jorge Soares MD, PhD
Departmento de Patologia Morfológica and Centro de Investigação de Patobiologia Molecular, Instituto Portuguěs de Oncologia de Francisco Gentil, Lisbon, Portugal
Departamento de Patologia Morfológica, Instituto Portuguěs de Oncologia, R. Prof. Lima Basto, 1093 Lisboa Codex, PortugalSearch for more papers by this authorCarmo Martins BSc
Departmento de Patologia Morfológica and Centro de Investigação de Patobiologia Molecular, Instituto Portuguěs de Oncologia de Francisco Gentil, Lisbon, Portugal
Search for more papers by this authorIsabel Fonseca MD, PhD
Departmento de Patologia Morfológica and Centro de Investigação de Patobiologia Molecular, Instituto Portuguěs de Oncologia de Francisco Gentil, Lisbon, Portugal
Search for more papers by this authorAna Félix MD
Departmento de Patologia Morfológica and Centro de Investigação de Patobiologia Molecular, Instituto Portuguěs de Oncologia de Francisco Gentil, Lisbon, Portugal
Search for more papers by this authorLúcia Roque BSc
Departmento de Patologia Morfológica and Centro de Investigação de Patobiologia Molecular, Instituto Portuguěs de Oncologia de Francisco Gentil, Lisbon, Portugal
Search for more papers by this authorCorresponding Author
Jorge Soares MD, PhD
Departmento de Patologia Morfológica and Centro de Investigação de Patobiologia Molecular, Instituto Portuguěs de Oncologia de Francisco Gentil, Lisbon, Portugal
Departamento de Patologia Morfológica, Instituto Portuguěs de Oncologia, R. Prof. Lima Basto, 1093 Lisboa Codex, PortugalSearch for more papers by this authorAbstract
Cytogenetic findings of 21 benign salivary gland tumors, including 14 pleomorphic adenomas, 5 Warthin's tumors, 1 myoepithelioma, and 1 cystadenoma, are reported. The present study confirms that pleomorphic adenomas characteristically have highly specific rearrangements involving only a few chromosome regions (3p21, 8q12 and 12q13–15) which suggests their specific role in the mixed tumors genesis. Warthin's tumors also show nonrandom numerical and structural alterations that were concurrent in one of the cases studied. To our knowledge no cytogenetic data are available in myoepitheliomas and cystadenomas. The former reveals a normal karyotype and the latter shows only clonal numerical alterations (gain of chromosomes 2 and 18). © 1995 Wiley-Liss, Inc.
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