Clinical significance of cathepsin D assay in breast cancer tissues
Yukashi Itoh MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Search for more papers by this authorShunzo Kobayashi MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Search for more papers by this authorHirotaka Iwase MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Search for more papers by this authorHiroko Yamashita MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Search for more papers by this authorTatsuya Kuzushima MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Search for more papers by this authorHiroji Iwata MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Search for more papers by this authorToshinari Yamashita MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Search for more papers by this authorAkihiro Naitoh MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Search for more papers by this authorCorresponding Author
Dr. Kazuko Itoh MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
1, Kawasumi, Mizuhocho, Mizuho-ku, Aichi-ken, Nagoya 467 JapanSearch for more papers by this authorAkira Masaoka MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Search for more papers by this authorYukashi Itoh MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Search for more papers by this authorShunzo Kobayashi MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Search for more papers by this authorHirotaka Iwase MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Search for more papers by this authorHiroko Yamashita MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Search for more papers by this authorTatsuya Kuzushima MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Search for more papers by this authorHiroji Iwata MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Search for more papers by this authorToshinari Yamashita MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Search for more papers by this authorAkihiro Naitoh MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Search for more papers by this authorCorresponding Author
Dr. Kazuko Itoh MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
1, Kawasumi, Mizuhocho, Mizuho-ku, Aichi-ken, Nagoya 467 JapanSearch for more papers by this authorAkira Masaoka MD
Second Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Search for more papers by this authorAbstract
Cathepsin D was assayed in 74 primary breast cancer specimens by enzyme immunoassay (EIA) and immunohistochemical assay (ICA). Of the 74 specimens, 38 (51.4%) were scored positive by ICA, and 25 (33.8%) were scored positive by EIA. The coincidence rate between ICA and EIA was 71.6% (53/74). There was no significant correlation between cathepsin D and menopausal status, tumor size, number of metastatic lymph nodes, histologic type of the tumor, or steroid receptor status. Cathepsin D status designated by EIA or ICA predicted neither disease-free survival (DFS) nor overall survival (OAS). Subset analysis with estrogen receptor, menopausal, and lymph node status revealed no association between cathepsin D and survival. Univariate analysis revealed no association between cathepsin D and DFS or OAS. Therefore, cathepsin D is not an independent prognostic factor in breast cancer. © 1995 Wiley-Liss, Inc.
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