REVIEW ARTICLE
Socioeconomic disparities in musculoskeletal oncology
Correction(s) for this article
-
Correction to “socioeconomic disparities in musculoskeletal oncology, J surg oncol. 2023 Sep;128(3):425-429. doi: 10.1002/jso.27361”
- Volume 128Issue 8Journal of Surgical Oncology
- pages: 1464-1464
- First Published online: October 26, 2023
Muhammad U. Jawad MD,
Raminta V. Theriault MD,
Steven W. Thorpe MD,
R. Lor Randall MD, FACS, FAOA,
Muhammad U. Jawad MD
Department of Orthopedic Surgery, Samaritan Health System, Corvallis, Oregon, USA
Search for more papers by this authorRaminta V. Theriault MD
Department of Orthopedic Surgery, UC Davis School of Medicine, Corvallis, Oregon, USA
Search for more papers by this authorSteven W. Thorpe MD
Department of Orthopedic Surgery, UC Davis School of Medicine, Corvallis, Oregon, USA
Search for more papers by this authorCorresponding Author
R. Lor Randall MD, FACS, FAOA
Department of Orthopedic Surgery, UC Davis School of Medicine, Corvallis, Oregon, USA
Correspondence R. Lor Randall, MD, FACS, FAOA, UC Davis Department of Orthopedic Surgery, Sarcoma Advanced Research & Clinical Fellowships, 4860 Y St, Suite 3800, Sacramento, CA 95817, USA.
Email: [email protected]
Search for more papers by this authorMuhammad U. Jawad MD,
Raminta V. Theriault MD,
Steven W. Thorpe MD,
R. Lor Randall MD, FACS, FAOA,
Muhammad U. Jawad MD
Department of Orthopedic Surgery, Samaritan Health System, Corvallis, Oregon, USA
Search for more papers by this authorRaminta V. Theriault MD
Department of Orthopedic Surgery, UC Davis School of Medicine, Corvallis, Oregon, USA
Search for more papers by this authorSteven W. Thorpe MD
Department of Orthopedic Surgery, UC Davis School of Medicine, Corvallis, Oregon, USA
Search for more papers by this authorCorresponding Author
R. Lor Randall MD, FACS, FAOA
Department of Orthopedic Surgery, UC Davis School of Medicine, Corvallis, Oregon, USA
Correspondence R. Lor Randall, MD, FACS, FAOA, UC Davis Department of Orthopedic Surgery, Sarcoma Advanced Research & Clinical Fellowships, 4860 Y St, Suite 3800, Sacramento, CA 95817, USA.
Email: [email protected]
Search for more papers by this authorAbstract
Musculoskeletal oncology is a clinical specialty dealing with a diverse population of patients with metastatic bone disease, hematological malignancies with musculoskeletal manifestations, primary bone malignancies and soft tissue sarcomas. There are wide-spread disparities including socioeconomic (SES) and insurance-related disparities reported in the literature. In this review, we'll summarize the disparities surrounding the musculoskeletal oncology.
CONFLICT OF INTEREST STATEMENT
The authors declare no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
NA.
REFERENCES
- 1Jawad MU, Pollock BH, Wise BL, et al. Sex, racial/ethnic and socioeconomic disparities in patients with metastatic bone disease. J Surg Oncol. 2021; 125(4): 766-774.
- 2Jawad MU, Pollock BH, Wise BL, et al. Socioeconomic and insurance-related disparities in disease-specific survival among patients with metastatic bone disease. J Surg Oncol. 2023; 127(1): 159-173.
- 3Edwards CM, Zhuang J, Mundy GR. The pathogenesis of the bone disease of multiple myeloma. Bone. 2008; 42(6): 1007-1013.
- 4Marino S, Roodman GD. Multiple myeloma and bone: the fatal interaction. Cold Spring Harbor Perspect Med. 2018; 8(8):a031286.
- 5Jawad MU, Cheung MC, Clarke J, Koniaris LG, Scully SP. Osteosarcoma: improvement in survival limited to high-grade patients only. J Cancer Res Clin Oncol. 2011; 137(4): 597-607.
- 6Jawad MU, Cheung MC, Min ES, Schneiderbauer MM, Koniaris LG, Scully SP. Ewing sarcoma demonstrates racial disparities in incidence-related and sex-related differences in outcome: an analysis of 1631 cases from the SEER database, 1973-2005. Cancer. 2009; 115(15): 3526-3536.
- 7Giuffrida AY, Burgueno JE, Koniaris LG, Gutierrez JC, Duncan R, Scully SP. Chondrosarcoma in the United States (1973 to 2003): an analysis of 2890 cases from the SEER database. J Bone Joint Surg Am Vol. 2009; 91(5): 1063-1072.
- 8Singh GK, Jemal A. Socioeconomic and Racial/Ethnic disparities in cancer mortality, incidence, and survival in the United States, 1950-2014: over six decades of changing patterns and widening inequalities. J Environ Public Health. 2017; 2017: 1-19.
- 9 Center for Disease Control U. Healthy people 2030. Social determinants of health. 2021. https://health.gov/healthypeople/objectives-and-data/social-determinants-health
- 10Jacobs AJ, Lindholm EB, Levy CF, Fish JD, Glick RD. Racial and ethnic disparities in treatment and survival of pediatric sarcoma. J Surg Res. 2017; 219: 43-49.
- 11Jawad MU, Farhan SB, Haffner MR, et al. Malignant neoplasms originating from the bones of the foot: predilection of hematological malignancies and sex-related and ethnic disparities in amputation. J Surg Oncol. 2021; 124(8): 1468-1476.
- 12Goulding D, Arguinchona L, Anderson-Mellies A, et al. Sociodemographic disparities in presentation and survival of pediatric bone cancers. J Pediatr Hematol Oncol. 2023; 45(1): e31-e43.
- 13Smartt AA, Jang ES, Tyler WK. Is there an association between insurance status and survival and treatment of primary bone and extremity soft-tissue sarcomas? A SEER database study. Clin Orthopae Rela Res. 2020; 478(3): 527-536.
- 14 Surveillance, Epidemiology and End Result (SEER). NCI. 2021. Accessed March 14, 2021.
- 15Miller BJ, Gao Y, Duchman KR. Socioeconomic measures influence survival in osteosarcoma: an analysis of The National cancer data base. Cancer Epidemiol. 2017; 49: 112-117.
- 16Jawad MU, Pollock BH, Alvarez E, Carr-Ascher JR, Randall RL, Thorpe SW. Non-Private health insurance predicts advanced stage at presentation and amputation in lower extremity high grade bone sarcoma: a national cancer database study: amputation predicts survival: an effect most pronounced in pediatric and AYA age group. Ann Surg Oncol. 2022; 29: 4363-4372.
- 17Gingrich AA, Marrufo AS, Liu Y, et al. Radiotherapy is associated with improved survival in patients with synovial sarcoma undergoing surgery: a national cancer database analysis. J Surg Res. 2020; 255: 378-387.
- 18Jackson CS, Oman M, Patel AM, Vega KJ. Health disparities in colorectal cancer among racial and ethnic minorities in the United States. J Gastrointest Oncol. 2016; 7(suppl 1): 32-43.
- 19Lucca I, Klatte T, Fajkovic H, de Martino M, Shariat SF. Erratum: gender differences in incidence and outcomes of urothelial and kidney cancer. Nat Rev Urol. 2015; 12(12): 653.
- 20Samson ME, Porter NG, Hurley DM, Adams SA, Eberth JM. Disparities in breast cancer incidence, mortality, and quality of care among African American and european American women in south carolina. South Med J. 2016; 109(1): 24-30.
- 21Zhong YJ, Wen YF, Wong HM, Yin G, Lin R, Yang SY. Trends and patterns of disparities in burden of lung cancer in the United States, 1974-2015. Front Oncol. 2019; 9: 404.
- 22Badal S, Aiken W, Morrison B, et al. Disparities in prostate cancer incidence and mortality rates: solvable or not? Prostate. 2020; 80(1): 3-16.
- 23Yedjou CG, Sims JN, Miele L, et al. Health and racial disparity in breast cancer. Adv Exp Med Biol. 2019; 1152: 31-49.
- 24Robbins AS, Siegel RL, Jemal A. Racial disparities in stage-specific colorectal cancer mortality rates from 1985 to 2008. J Clin Oncol. 2012; 30(4): 401-405.
- 25Hendrick RE, Monticciolo DL, Biggs KW, Malak SF. Age distributions of breast cancer diagnosis and mortality by race and ethnicity in US women. Cancer. 2021; 127(23): 4384-4392.
- 26DeSantis CE, Ma J, Gaudet MM, et al. Breast cancer statistics, 2019. CA Cancer J Clin. 2019; 69(6): 438-451.
- 27 NIMHD. NIMHD Minority Health and Health Disparities Research. 2021. https://www.nimhd.nih.gov/about/overview/research-framework/.
- 28Isaacs SL, Schroeder SA. Class—the ignored determinant of the nation's health. N Engl J Med. 2004; 351(11): 1137-1142.
- 29Freeman HP. Cancer in the socioeconomically disadvantaged. CA Cancer J Clin. 1989; 39(5): 266-288.
- 30Adler NE. Socioeconomic inequalities in health. JAMA. 1993; 269(24): 3140-3145.
- 31Moss JL, Johnson NJ, Yu M, Altekruse SF, Cronin KA. Comparisons of individual- and area-level socioeconomic status as proxies for individual-level measures: evidence from the mortality disparities in American communities study. Popul Health Metr. 2021; 19(1): 1.
- 32Blanc PD, Yen IH, Chen H, et al. Area-level socio-economic status and health status among adults with asthma and rhinitis. Eur Respir J. 2006; 27(1): 85-94.
- 33Cole S, Gianferante DM, Zhu B, Mirabello L. Osteosarcoma: a surveillance, epidemiology, and end results program-based analysis from 1975 to 2017. Cancer. 2022; 128(11): 2107-2118.
- 34Miller BJ, Cram P, Lynch CF, Buckwalter JA. Risk factors for metastatic disease at presentation with osteosarcoma: an analysis of the SEER database. J Bone Jt Surg. 2013; 95(13):e89.
- 35Wendt R, Gao Y, Miller BJ. Rural patients are at risk for increased stage at presentation and diminished overall survival in osteosarcoma. Cancer Epidemiol. 2019; 61: 119-123.
- 36Duchman KR, Gao Y, Miller BJ. Prognostic factors for survival in patients with high-grade osteosarcoma using the surveillance, epidemiology, and end results (SEER) program database. Cancer Epidemiol. 2015; 39(4): 593-599.
- 37McMahon KM, Nilles-Melchert T, Eaton V, Silberstein PT. Effects of socioeconomic and geographic factors on outcomes in ewing sarcoma: a national cancer database review. Cureus. 2022; 14(5):e25525.
- 38Worch J, Matthay KK, Neuhaus J, Goldsby R, DuBois SG. Ethnic and racial differences in patients with ewing sarcoma. Cancer. 2010; 116(4): 983-988.
- 39Worch J, Ranft A, DuBois SG, Paulussen M, Juergens H, Dirksen U. Age dependency of primary tumor sites and metastases in patients with Ewing sarcoma. Pediatr Blood Cancer. 2018; 65(9):e27251.
- 40Hu X, Fujiwara T, Houdek MT, et al. Impact of racial disparities and insurance status in patients with bone sarcomas in the USA: a population-based cohort study. Bone Joint Res. 2022; 11(5): 278-291.
- 41Lapica H, Ozery M, Raju H, Castro G, Rodriguez de la Vega P, Barengo NC. The associations between racial disparities, health insurance, and the use of amputation as treatment for malignant primary bone neoplasms in the US: a retrospective analysis from 1998 to 2016. Int J Environ Res Public Health. 2022; 19(10): 6289.
- 42Jawad MU, Bayne CO, Farhan S, et al. Prognostic factors, disparity, and equity variables impacting prognosis in bone sarcomas of the hand: SEER database review. J Surg Oncol. 2021; 124(8): 1515-1522.
- 43Dasenbrock HH, Wolinsky JP, Sciubba DM, Witham TF, Gokaslan ZL, Bydon A. The impact of insurance status on outcomes after surgery for spinal metastases. Cancer. 2012; 118(19): 4833-4841.
- 44Hung B, Pennington Z, Hersh AM, et al. Impact of race on nonroutine discharge, length of stay, and postoperative complications after surgery for spinal metastases. J Neurosurg Spi. 2022; 36(4): 678-685.
- 45De la Garza Ramos R, Benton JA, Gelfand Y, et al. Racial disparities in clinical presentation, type of intervention, and in-hospital outcomes of patients with metastatic spine disease: an analysis of 145,809 admissions in the United States. Cancer Epidemiol. 2020; 68:101792.
- 46De la Garza Ramos R, Choi JH, Naidu I, et al. Racial disparities in perioperative morbidity following oncological spine surgery. Global Spine J. Published online June 14, 2021. doi:10.1177/21925682211022290
- 47Jawad MU, Zeitlinger LN, Bewley AF, et al. Head and neck cutaneous soft-tissue sarcoma demonstrate sex and Racial/Ethnic disparities in incidence and socioeconomic disparities in survival. J Clin Med. 2022; 11(18): 5475.
- 48Li S, Peng Y, Weinhandl ED, et al. Estimated number of prevalent cases of metastatic bone disease in the US adult population. Clin Epidemiol. 2012; 4: 87-93.
- 49Huang JF, Shen J, Li X, et al. Incidence of patients with bone metastases at diagnosis of solid tumors in adults: a large population-based study. Ann Transl Med. 2020; 8(7): 482.
- 50Meeuse JJ, van der Linden YM, van Tienhoven G, Gans ROB, Leer JWH, Reyners AKL. Efficacy of radiotherapy for painful bone metastases during the last 12 weeks of life: results from the Dutch bone metastasis study. Cancer. 2010; 116(11): 2716-2725.
- 51Coleman RE. Prevention and treatment of bone metastases. Nat Rev Clin Oncol. 2011; 9(2): 76-78.
- 52Elshahat S, Treanor C, Donnelly M. Factors influencing physical activity participation among people living with or beyond cancer: a systematic scoping review. International J Behav Nutri Phy Acti. 2021; 18(1): 50.
- 53Gencay Can A. Is kinesiophobia associated with lymphedema, upper extremity function, and psychological morbidity in breast cancer survivors? Turkish J Phys Med Rehabilita. 2019; 65(2): 139-146.
- 54Fischer DJ, Villines D, Kim YO, Epstein JB, Wilkie DJ. Anxiety, depression, and pain: differences by primary cancer. Supp Care Cancer. 2010; 18(7): 801-810.
- 55Galloway SK, Meadors P, Boselli D, Walsh D. Anxiety, depression, pain, and social support in a large representative cancer population. J Clin Oncol. 2019; 37(suppl 31): 76.
- 56Zaza C, Baine N. Cancer pain and psychosocial factors. J Pain Symptom Manage. 2002; 24(5): 526-542.
- 57Zaza C, Reyno L, Moulin DE. The multidimensional pain inventory profiles in patients with chronic cancer-related pain: an examination of generalizability. Pain. 2000; 87(1): 75-82.
- 58Arora A, Saini S, Nautiyal V, et al. Cancer pain, anxiety, and depression in admitted patients at a tertiary care hospital: a prospective observational study. Indian J Palliat Care. 2019; 25(4): 562-566.
- 59Banks SM, Kerns RD. Explaining high rates of depression in chronic pain: a diathesis-stress framework. Psychol Bull. 1996; 119(1): 95-110.
- 60Dworkin RH, Hetzel RD, Banks SM. Toward a model of the pathogenesis of chronic pain. Semin Clin Neuropsychiatry. 1999; 4(3): 176-185.
- 61Spiegel D, Sands S, Koopman C. Pain and depression in patients with cancer. Cancer. 1994; 74(9): 2570-2578.
10.1002/1097-0142(19941101)74:9<2570::AID-CNCR2820740927>3.0.CO;2-3 CAS PubMed Web of Science® Google Scholar
- 62Randall RL. A promise to our patients with metastatic bone disease. Ann Surg Oncol. 2014; 21(13): 4049-4050.
- 63Badr H, Shen MJ. Pain catastrophizing, pain intensity, and dyadic adjustment influence patient and partner depression in metastatic breast cancer. Clin J Pain. 2014; 30(11): 923-933.
- 64Wright MA, Adelani M, Dy C, O'Keefe R, Calfee RP. What is the impact of social deprivation on physical and mental health in orthopaedic patients? Clin Orthopae Rela Res. 2019; 477(8): 1825-1835.
- 65Ridley M, Rao G, Schilbach F, Patel V Poverty, depression, and anxiety: causal evidence and mechanisms. Science 2020; 370(6522): eaay0214. doi:10.1126/science.aay0214
