Rate and pattern of gastric emptying in humans using 99mTc-Labeled triethylenetetraamine–polystyrene resin
Abstract
The preparation and application of a new radiopharmaceutical used in the investigation of the rate and pattern of gastric emptying by external scintigraphy are described. Triethylenetetraamine was bound covalently to cross-linked chloromethylated polystyrene. The triethylenetetraamine–polystyrene resin tenaciously and rapidly bound technetium 99m. The gastric emptying rate was evaluated in normal adult volunteers and patients by serially recording the gastric radioactivity after ingestion of a test meal mixed with 99mTc-labeled triethylenetetraamine–polystyrene resin. The data indicated that 99mTc-labeled triethylenetetraamine–polystyrene resin was an ideal agent for assessing the rate and pattern of gastric emptying in humans. The gastric emptying half-time (t1/2GE) in normal subjects ranged from 25 to 75 min.
