Kinetics of salicyluric acid elimination in man

The kinetics of salicyluric acid (SU) elimination were determined in healthy adult men from urinary excretion and (in one instance) plasma concentration data following intravenous injection of SU or oral administration of salicylate and subsequent blocking of further SU formation by benzoate. Similar results were obtained by the two methods. The elimination of SU is considerably more rapid than is suggested by urinary excretion data obtained after oral administration of SU in aqueous solution. The kinetics of SU formation from salicylate can be characterized adequately by considering the formation process as the rate-limiting step in the excretion of SU after salicylate administration.