BK virus infection of the human urinary tract
Toshiya Shinohara
Department of Pathology, Hokkaido University School of Medicine, Sapporo, Tokyo, Japan
Search for more papers by this authorMichiyuki Matsuda
Department of Pathology, National Institute of Health, Tokyo, Japan
Search for more papers by this authorSeng H. Cheng
Laboratory of Cellular Regulation, Genzyme Corporation, Framingham, Massachusetts
Search for more papers by this authorJohn Marshall
Laboratory of Cellular Regulation, Genzyme Corporation, Framingham, Massachusetts
Search for more papers by this authorMiri Fujita
Department of Pathology, Hokkaido University School of Medicine, Sapporo, Tokyo, Japan
Search for more papers by this authorCorresponding Author
Kazuo Nagashima MD
Department of Pathology, Hokkaido University School of Medicine, Sapporo, Tokyo, Japan
Department of Pathology, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060, Japan===Search for more papers by this authorToshiya Shinohara
Department of Pathology, Hokkaido University School of Medicine, Sapporo, Tokyo, Japan
Search for more papers by this authorMichiyuki Matsuda
Department of Pathology, National Institute of Health, Tokyo, Japan
Search for more papers by this authorSeng H. Cheng
Laboratory of Cellular Regulation, Genzyme Corporation, Framingham, Massachusetts
Search for more papers by this authorJohn Marshall
Laboratory of Cellular Regulation, Genzyme Corporation, Framingham, Massachusetts
Search for more papers by this authorMiri Fujita
Department of Pathology, Hokkaido University School of Medicine, Sapporo, Tokyo, Japan
Search for more papers by this authorCorresponding Author
Kazuo Nagashima MD
Department of Pathology, Hokkaido University School of Medicine, Sapporo, Tokyo, Japan
Department of Pathology, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060, Japan===Search for more papers by this authorAbstract
By screening consecutive autopsy cases with an antibody that recognizes human polyomaviruses, we found a case of malignant lymphoma in which the virus infection was confined to epithelia of the renal calyces, renal pelvis, ureter, and urinary bladder. The virus was confirmed as BK virus by a specific monoclonal antibody against BK virus T antigen, and numerous virus particles were identified by electron microscopy. The results showed that BK virus is a human urotheliotrophic virus.
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