Original Research

Altered Functional Connectivity of Hippocampal Subfields in Poststroke Dementia

Zhiyong Zhao PhD

orcid.org/0000-0002-1432-0430

Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China

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Huaying Cai MD,

Huaying Cai MD

Department of Neurology, Neuroscience Center, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China

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Manli Huang MD,

Manli Huang MD

Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou, China

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Weihao Zheng PhD,

Weihao Zheng PhD

Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China

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Tingting Liu MS,

Tingting Liu MS

Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China

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Di Sun BS,

Di Sun BS

Department of Neurology, Neuroscience Center, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China

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Guocan Han BS,

Guocan Han BS

Department of Radiology, Neuroscience Center, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China

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Linhui Ni MS,

Linhui Ni MS

Department of Neurology, Neuroscience Center, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China

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Yi Zhang PhD,

Yi Zhang PhD

orcid.org/0000-0001-8738-1851

Department of Neurology, The First Affiliated Hospital, Zhejiang University, Hangzhou, China

Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China

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Dan Wu PhD,

Corresponding Author

Dan Wu PhD

[email protected]

orcid.org/0000-0002-9303-5821

Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China

Address reprint requests to: D.W., Room 525, Zhou Yiqing Building, Yuquan Campus, Zhejiang University, Hangzhou, 310027, China. E-mail: [email protected]

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Zhiyong Zhao PhD,

Zhiyong Zhao PhD

orcid.org/0000-0002-1432-0430

Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China

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Huaying Cai MD,

Huaying Cai MD

Department of Neurology, Neuroscience Center, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China

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Manli Huang MD,

Manli Huang MD

Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou, China

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Weihao Zheng PhD,

Weihao Zheng PhD

Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China

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Tingting Liu MS,

Tingting Liu MS

Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China

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Di Sun BS,

Di Sun BS

Department of Neurology, Neuroscience Center, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China

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Guocan Han BS,

Guocan Han BS

Department of Radiology, Neuroscience Center, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China

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Linhui Ni MS,

Linhui Ni MS

Department of Neurology, Neuroscience Center, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China

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Yi Zhang PhD,

Yi Zhang PhD

orcid.org/0000-0001-8738-1851

Department of Neurology, The First Affiliated Hospital, Zhejiang University, Hangzhou, China

Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China

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Dan Wu PhD,

Corresponding Author

Dan Wu PhD

[email protected]

orcid.org/0000-0002-9303-5821

Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China

Address reprint requests to: D.W., Room 525, Zhou Yiqing Building, Yuquan Campus, Zhejiang University, Hangzhou, 310027, China. E-mail: [email protected]

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First published: 18 May 2021

https://doi.org/10.1002/jmri.27691

Citations: 2

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Abstract

Background

The hippocampus (HP) plays a critical role in memory and orientational functions and is functionally heterogeneous along the longitudinal anterior–posterior axis. Although the previous study has reported volumetric atrophy in hippocampal subfields of patients with poststroke dementia (PSD), how the functional connectivity (FC) is altered in these subfields remains unclear.

Purpose

To examine the FC changes of the HP subfields in patients with PSD.

Study Type

Prospective.

Population

Seventeen normal controls, 20 PSD, and 24 nondemented poststroke (PSND) patients.

Field Strength/Sequence

A 3.0 T/ T1-weighted imaging, resting-state functional and diffusion tensor imaging.

Assessment

We first segmented the HP using independent component analysis, and then used granger causality analysis to calculate the directed FCs (dFCs) between the subfields and the whole brain, and compared the dFCs among PSD, PSND, and controls.

Statistical Tests

Student's t-test, chi-square test, one-way ANCOVA, multiple regression, support vector machine, multiple comparison correction, and reproducibility analysis. A P value < 0.05 was considered statistically significant.

Results

Our results showed HP was functionally divided into HP_head, HP_body, and HP_tail bilaterally along the longitudinal axis. PSD patients showed significant dementia-specific decreases in the inward information flow and increases in the outward information flow associated with the bilateral entire HP/HP_head and left HP_body (P < 0.05). Moreover, we observed significant correlations (P < 0.05) between the cognition score and the dFCs related to the bilateral entire HP and left HP_head in the PSD group. Furthermore, dFCs of the HP and its subfields improved the classification between the PSD and PSND patients (accuracy/sensitivity/specificity: 94%/95%/93%) compared to the clinical and demographic parameters alone.

Data Conclusion

These findings suggest that altered transmission and reception of information in the HP. These alternations were specific to individual subfields in PSD patients and may offer insight into the neurophysiological mechanisms underlying PSD.

Evidence Level

Technical Efficacy

Stage 2

Conflict of interest

The authors declare no potential conflicts of interest.

Supporting Information

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Citing Literature

Volume54, Issue4

October 2021

Pages 1337-1348

Altered Functional Connectivity of Hippocampal Subfields in Poststroke Dementia

Abstract

Background

Purpose

Study Type

Population

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

Evidence Level

Technical Efficacy

Conflict of interest

Supporting Information

References

Citing Literature

References

Information

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Altered Functional Connectivity of Hippocampal Subfields in Poststroke Dementia

Abstract

Background

Purpose

Study Type

Population

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

Evidence Level

Technical Efficacy

Conflict of interest

Supporting Information

References

Citing Literature

References

Related

Information