Volume 54, Issue 1 pp. 284-289

Original Research

Noninvasive oxygenation assessment after acute myocardial infarction with breathing maneuvers-induced oxygenation-sensitive magnetic resonance imaging

Ke Shi MD,

Ke Shi MD

Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 China

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Meng-Xi Yang MD,

Meng-Xi Yang MD

Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 China

Department of Radiology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 China

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Chun-Chao Xia MS,

Chun-Chao Xia MS

Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 China

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Wan-Lin Peng MS,

Wan-Lin Peng MS

Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 China

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Kun Zhang MS,

Kun Zhang MS

Department of Radiology, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041 China

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Zhen-Lin Li MS,

Zhen-Lin Li MS

Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 China

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Ying-Kun Guo MD, PhD,

Ying-Kun Guo MD, PhD

orcid.org/0000-0001-8437-9887

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Zhi-Gang Yang MD, PhD,

Corresponding Author

Zhi-Gang Yang MD, PhD

[email protected]

orcid.org/0000-0001-9341-7697

Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 China

Correspondence Zhi-Gang Yang, Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.

Email: [email protected]

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Ke Shi MD,

Ke Shi MD

Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 China

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Meng-Xi Yang MD,

Meng-Xi Yang MD

Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 China

Department of Radiology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 China

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Chun-Chao Xia MS,

Chun-Chao Xia MS

Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 China

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Wan-Lin Peng MS,

Wan-Lin Peng MS

Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 China

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Kun Zhang MS,

Kun Zhang MS

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Zhen-Lin Li MS,

Zhen-Lin Li MS

Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 China

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Ying-Kun Guo MD, PhD,

Ying-Kun Guo MD, PhD

orcid.org/0000-0001-8437-9887

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Zhi-Gang Yang MD, PhD,

Corresponding Author

Zhi-Gang Yang MD, PhD

[email protected]

orcid.org/0000-0001-9341-7697

Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 China

Correspondence Zhi-Gang Yang, Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.

Email: [email protected]

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First published: 12 January 2021

https://doi.org/10.1002/jmri.27509

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Abstract

The safety profiles when performing stress oxygenation-sensitive magnetic resonance imaging (OS-MRI) have raised concerns in clinical practice. Adenosine infusion can cause side effects such as chest pain, dyspnea, arrhythmia, and even cardiac death. The aim of this study was to investigate the feasibility of breathing maneuvers-induced OS-MRI in acute myocardial infarction (MI). This was a prospective study, which included 14 healthy rabbits and nine MI rabbit models. This study used 3 T MRI/modified Look-Locker inversion recovery sequence for native T₁ mapping, balanced steady-state free precession sequence for OS imaging, and phase-sensitive inversion recovery sequence for late gadolinium enhancement. The changes in myocardial oxygenation (ΔSI) were assessed under two breathing maneuvers protocols in healthy rabbits: a series of extended breath-holding (BH), and a combined maneuver of hyperventilation followed by the extended BH (HVBH). Subsequently, OS-MRI with HVBH in acute MI rabbits was performed, and the ΔSI was compared with that of adenosine stress protocol. Student's t-test, Wilcoxon rank test, and Friedman test were used to compare ΔSI in different subgroups. Pearson and Spearman correlation was used to obtain the association of ΔSI between breathing maneuvers and adenosine stress. Bland–Altman analysis was used to assess the bias of ΔSI between HVBH and adenosine stress. In healthy rabbits, BH maneuvers from 30 to 50 s induced significant increase in SI compared with the baseline (all p < 0.05). By contrast, hyperventilation for 60 s followed by 10 s-BH (HVBH 10 s) exhibited a comparable ΔSI to that of stress test (p = 0.07). In acute MI rabbits, HVBH 10 s-induced ΔSIs among infarcted, salvaged, and the remote myocardial area were no less effectiveness than adenosine stress when performing OS-MRI (r = 0.84; p < 0.05). Combined breathing maneuvers with OS-MRI have the potential to be used as a nonpharmacological alternative for assessing myocardial oxygenation in patients with acute MI.

Level of Evidence

Technical Efficacy Stage

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Volume54, Issue1

July 2021

Pages 284-289

Noninvasive oxygenation assessment after acute myocardial infarction with breathing maneuvers-induced oxygenation-sensitive magnetic resonance imaging

Abstract

Level of Evidence

Technical Efficacy Stage

References

References

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Noninvasive oxygenation assessment after acute myocardial infarction with breathing maneuvers-induced oxygenation-sensitive magnetic resonance imaging

Abstract

Level of Evidence

Technical Efficacy Stage

References

References

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