Volume 51, Issue 1 pp. 81-89

Original Research

Assessment of hepatic sinusoidal obstruction syndrome with intravoxel incoherent motion diffusion-weighted imaging: An experimental study in a rat model

Eun Kyoung Hong MD,

Eun Kyoung Hong MD

Department of Radiology, Seoul National University Hospital, Seoul, Korea

Department of Radiology, Seoul National University College of Medicine, Seoul, Korea

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Ijin Joo MD,

Corresponding Author

Ijin Joo MD

[email protected]

orcid.org/0000-0002-1341-4072

Department of Radiology, Seoul National University Hospital, Seoul, Korea

Department of Radiology, Seoul National University College of Medicine, Seoul, Korea

Address reprint requests to: I.J., Department of Radiology, Seoul National University Hospital, Department of Radiology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea. E-mail: [email protected]Search for more papers by this author

Juil Park MD,

Juil Park MD

Department of Radiology, Seoul National University Hospital, Seoul, Korea

Department of Radiology, Seoul National University College of Medicine, Seoul, Korea

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Kyoungbun Lee MD,

Kyoungbun Lee MD

Department of Pathology, Seoul National University Hospital, Seoul, Korea

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Eun Kyoung Hong MD,

Eun Kyoung Hong MD

Department of Radiology, Seoul National University Hospital, Seoul, Korea

Department of Radiology, Seoul National University College of Medicine, Seoul, Korea

Search for more papers by this author

Ijin Joo MD,

Corresponding Author

Ijin Joo MD

[email protected]

orcid.org/0000-0002-1341-4072

Department of Radiology, Seoul National University Hospital, Seoul, Korea

Department of Radiology, Seoul National University College of Medicine, Seoul, Korea

Juil Park MD,

Juil Park MD

Department of Radiology, Seoul National University Hospital, Seoul, Korea

Department of Radiology, Seoul National University College of Medicine, Seoul, Korea

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Kyoungbun Lee MD,

Kyoungbun Lee MD

Department of Pathology, Seoul National University Hospital, Seoul, Korea

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First published: 15 May 2019

https://doi.org/10.1002/jmri.26790

Citations: 8

Contract grant sponsor: Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning; Contract grant number: 2015R1C1A2A01055423; Contract grant sponsor: Radiological Research Foundation of Korea; Contract grant number: 2015-04.

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Abstract

Background

Intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters may reflect perfusion and diffusion changes in hepatic sinusoidal obstruction syndrome (SOS).

Purpose

To investigate the feasibility of IVIM-DWI in the noninvasive assessment of hepatic SOS in an experimental rat model.

Study Type

Animal study.

Population/Subjects

Forty-four rats were administered different doses (90 or 160 mg/kg) of monocrotaline by gavage either 48 or 72 hours before MRI to induce different degrees of hepatic SOS, and another 10 rats served as controls.

Field Strength/Sequence

3T scanner, IVIM-DWI using nine b values (0–800 sec/mm²).

Assessment

Histologically, rats were classified as having none (n = 10), mild (n = 8), moderate (n = 19), or severe SOS (n = 17). The apparent diffusion coefficient (ADC) and IVIM-derived parameters (D: true diffusion coefficient, D*: pseudo-diffusion coefficient, and f: perfusion fraction) of the liver parenchyma were measured.

Statistical Tests

IVIM-DWI parameters were compared according to histologic grades of SOS (none, mild, moderate, and severe), and receiver operating characteristic (ROC) curve analysis was performed to determine the diagnostic accuracy.

Results

ADC, D, and f of the liver parenchyma were significantly different according to SOS severity groups (Ps < 0.01) and significantly decreased as SOS severity increased (rho = –0.323, –0.313, and –0.700; P = 0.017, 0.021, and <0.001, respectively). Means of f in none, mild, moderate, and severe SOS were 17.2%, 13.3%, 12.3%, and 11.1%, respectively. Among ADC and IVIM-derived parameters, f provided the highest area under the ROC curves for detecting ≥mild, ≥moderate, and severe SOS (0.991, 0.890, and 0.803, respectively).

Data Conclusion

IVIM-DWI may be useful in the diagnosis and severity assessment of hepatic SOS.

Level of Evidence: 2

Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2020;51:81–89.

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Citing Literature

Volume51, Issue1

January 2020

Pages 81-89

Assessment of hepatic sinusoidal obstruction syndrome with intravoxel incoherent motion diffusion-weighted imaging: An experimental study in a rat model

Abstract

Background

Purpose

Study Type

Population/Subjects

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

References

Citing Literature

References

Information

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Assessment of hepatic sinusoidal obstruction syndrome with intravoxel incoherent motion diffusion-weighted imaging: An experimental study in a rat model

Abstract

Background

Purpose

Study Type

Population/Subjects

Field Strength/Sequence

Assessment

Statistical Tests

Results

Data Conclusion

References

Citing Literature

References

Related

Information