Original Research

Relative cerebral blood volume is a potential biomarker in late delayed radiation-induced brain injury

Ying Xie MD

Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 China

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Haiwei Huang MD,

Corresponding Author

Haiwei Huang MD

[email protected]

Address reprint requests to: H.H., Sun Yat-sen University, Guangzhou, China. E-mail: [email protected]Search for more papers by this author

Junjie Guo MD,

Junjie Guo MD

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Dongxiao Zhou MD,

Dongxiao Zhou MD

Search for more papers by this author

Ying Xie MD,

Ying Xie MD

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Haiwei Huang MD,

Corresponding Author

Haiwei Huang MD

[email protected]

Address reprint requests to: H.H., Sun Yat-sen University, Guangzhou, China. E-mail: [email protected]Search for more papers by this author

Junjie Guo MD,

Junjie Guo MD

Search for more papers by this author

Dongxiao Zhou MD,

Dongxiao Zhou MD

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First published: 10 August 2017

https://doi.org/10.1002/jmri.25837

Citations: 10

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Abstract

Purpose

To assess whether relative cerebral blood volume (rCBV) can provide information to reliably evaluate the stages of late delayed radiation-induced brain injury.

Materials and Methods

Forty patients diagnosed with late delayed radiation-induced brain injury were enrolled. The patients were examined using a 1.5T magnetic resonance imaging (MRI) system equipped with an 8-channel head coil. An echo planar imaging (EPI) sequence was used in perfusion-weighted imaging (PWI). The location of 1H-MR spectroscopy scanning was acquired by a point-resolved spectroscopy sequence. Lesions of the temporal lobe were divided into one of two groups according to rCBV value: rCBV<1 (low rCBV [group 1; n = 45]); and rCBV>1 (elevated rCBV [group 2; n = 14]). PWI and MRS parameters, as well as morphological lesion types, in these two groups were compared. Morphological severity was assessed independently and agreed on by two imaging specialists (J.L. and H.X.S., with 16 and 24 years' experience, respectively). If necessary, a third imaging professor (Z.M.H.) with 30 years' experience resolved disagreement(s). Standards for evaluating morphological lesion types were based on previously published criteria. After testing the skewness of data, the Mann–Whitney U-test or Student's t-test was used, as appropriate.

Results

rCBV, relative cerebral blood flow (rCBF), and relative mean transit time (rMTT) in group 2 (n = 14) were significantly higher than in group 1 (n = 45) (rCBV: 1.21 ± 0.38 vs. 0.72 ± 0.32, respectively; P < 0.001; rCBF: 1.13 ± 0.02 vs. 0.74 ± 0.04, respectively; P < 0.001; rMTT: 1.10 ± 0.26 vs. 0.96 ± 0.20, P < 0.001). The levels of choline-containing compounds (CHO) / creatine (Cr) and CHO/N-acetylaspartate (NAA) in group 1 were significantly greater than in group 2 (CHO/Cr: 1.89 ± 1.83 vs. 1.22 ± 1.31, respectively; P = 0.016; CHO/NAA: 1.85 ± 3.50 vs. 1.17 ± 0.75, respectively; P = 0.022). More severe morphological lesions were present in lesions with low rCBV compared with elevated rCBV (overall severity: 7.00 ± 4.25 vs. 5.00 ± 5.13, respectively; P = 0.029).

Conclusion

Elevated rCBV accompanied by a more conservative metabolic pattern and milder lesion(s) may represent a less advanced stage in the development of late delayed radiation-induced brain injury.

Level of Evidence: 4

Technical Efficacy: Stage 3

J. Magn. Reson. Imaging 2018;47:1112–1118.

Supporting Information

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Citing Literature

Volume47, Issue4

April 2018

Pages 1112-1118

Filename	Description
jmri25837-sup-0001-supptable1.docx22.2 KB	Supporting Information Table 2
jmri25837-sup-0002-supptable2.docx22.4 KB	Supporting Information Table 3
jmri25837-sup-0003-supptable3.docx21.9 KB	Supporting Information Table 4

Relative cerebral blood volume is a potential biomarker in late delayed radiation-induced brain injury

Abstract

Purpose

Materials and Methods

Results

Conclusion

Supporting Information

References

Citing Literature

References

Information

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Relative cerebral blood volume is a potential biomarker in late delayed radiation-induced brain injury

Abstract

Purpose

Materials and Methods

Results

Conclusion

Supporting Information

References

Citing Literature

References

Related

Information