CME Article
Mechanisms of osteoarthritis in the knee: MR imaging appearance
Lauren M. Shapiro BA,
Emily J. McWalter PhD,
Min-Sun Son BS, MS,
Marc Levenston PhD,
Brian A. Hargreaves PhD,
Garry E. Gold MD,
Corresponding Author
Lauren M. Shapiro BA
Department of Radiology, Stanford University, Stanford, California, USA
Address reprint requests to: L.M.S., B.A., Department of Radiology, Grant Building S062, Stanford, CA 94305. E-mail: [email protected]Search for more papers by this authorEmily J. McWalter PhD
Department of Radiology, Stanford University, Stanford, California, USA
Search for more papers by this authorMin-Sun Son BS, MS
Department of Bioengineering, Stanford University, Stanford, California, USA
Search for more papers by this authorMarc Levenston PhD
Department of Mechanical Engineering, Stanford University, Stanford, California, USA
Search for more papers by this authorBrian A. Hargreaves PhD
Department of Radiology, Stanford University, Stanford, California, USA
Search for more papers by this authorGarry E. Gold MD
Department of Radiology, Stanford University, Stanford, California, USA
Department of Bioengineering, Stanford University, Stanford, California, USA
Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA
Search for more papers by this authorLauren M. Shapiro BA,
Emily J. McWalter PhD,
Min-Sun Son BS, MS,
Marc Levenston PhD,
Brian A. Hargreaves PhD,
Garry E. Gold MD,
Corresponding Author
Lauren M. Shapiro BA
Department of Radiology, Stanford University, Stanford, California, USA
Address reprint requests to: L.M.S., B.A., Department of Radiology, Grant Building S062, Stanford, CA 94305. E-mail: [email protected]Search for more papers by this authorEmily J. McWalter PhD
Department of Radiology, Stanford University, Stanford, California, USA
Search for more papers by this authorMin-Sun Son BS, MS
Department of Bioengineering, Stanford University, Stanford, California, USA
Search for more papers by this authorMarc Levenston PhD
Department of Mechanical Engineering, Stanford University, Stanford, California, USA
Search for more papers by this authorBrian A. Hargreaves PhD
Department of Radiology, Stanford University, Stanford, California, USA
Search for more papers by this authorGarry E. Gold MD
Department of Radiology, Stanford University, Stanford, California, USA
Department of Bioengineering, Stanford University, Stanford, California, USA
Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA
Search for more papers by this authorAbstract
Osteoarthritis has grown to become a widely prevalent disease that has major implications in both individual and public health. Although originally considered to be a degenerative disease driven by “wear and tear” of the articular cartilage, recent evidence has led to a consensus that osteoarthritis pathophysiology should be perceived in the context of the entire joint and multiple tissues. MRI is becoming an increasingly more important modality for imaging osteoarthritis, due to its excellent soft tissue contrast and ability to acquire morphological and biochemical data. This review will describe the pathophysiology of osteoarthritis as it is associated with various tissue types, highlight several promising MR imaging techniques for osteoarthritis and illustrate the expected appearance of osteoarthritis with each technique. J. Magn. Reson. Imaging 2014;39:1346–1356. © 2014 Wiley Periodicals, Inc.
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