Characterization of thalamo-cortical association using amplitude and connectivity of functional MRI in mild traumatic brain injury
Yongxia Zhou PhD
Department of Radiology / Center for Biomedical Imaging, NYU Langone Medical Center, New York, New York, USA
Search for more papers by this authorYvonne W. Lui MD
Department of Radiology / Center for Biomedical Imaging, NYU Langone Medical Center, New York, New York, USA
Search for more papers by this authorXi-Nian Zuo PhD
Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science, Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
Search for more papers by this authorMichael P. Milham MD, PhD
Child Mind Institute, New York, New York, USA
Search for more papers by this authorJoseph Reaume BS
Department of Radiology / Center for Biomedical Imaging, NYU Langone Medical Center, New York, New York, USA
Search for more papers by this authorRobert I. Grossman MD
Department of Radiology / Center for Biomedical Imaging, NYU Langone Medical Center, New York, New York, USA
Search for more papers by this authorCorresponding Author
Yulin Ge MD
Department of Radiology / Center for Biomedical Imaging, NYU Langone Medical Center, New York, New York, USA
Address reprint requests to: Y.G., Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, 660 First Avenue, 4th floor, New York, NY 10016 USA. E-mail: [email protected]Search for more papers by this authorYongxia Zhou PhD
Department of Radiology / Center for Biomedical Imaging, NYU Langone Medical Center, New York, New York, USA
Search for more papers by this authorYvonne W. Lui MD
Department of Radiology / Center for Biomedical Imaging, NYU Langone Medical Center, New York, New York, USA
Search for more papers by this authorXi-Nian Zuo PhD
Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science, Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
Search for more papers by this authorMichael P. Milham MD, PhD
Child Mind Institute, New York, New York, USA
Search for more papers by this authorJoseph Reaume BS
Department of Radiology / Center for Biomedical Imaging, NYU Langone Medical Center, New York, New York, USA
Search for more papers by this authorRobert I. Grossman MD
Department of Radiology / Center for Biomedical Imaging, NYU Langone Medical Center, New York, New York, USA
Search for more papers by this authorCorresponding Author
Yulin Ge MD
Department of Radiology / Center for Biomedical Imaging, NYU Langone Medical Center, New York, New York, USA
Address reprint requests to: Y.G., Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, 660 First Avenue, 4th floor, New York, NY 10016 USA. E-mail: [email protected]Search for more papers by this authorAbstract
Purpose
To examine thalamic and cortical injuries using fractional amplitude of low-frequency fluctuations (fALFFs) and functional connectivity MRI (fcMRI) based on resting state (RS) and task-related fMRI in patients with mild traumatic brain injury (MTBI).
Materials and Methods
Twenty-seven patients and 27 age-matched controls were recruited. The 3 Tesla fMRI at RS and finger tapping task were used to assess fALFF and fcMRI patterns. fALFFs were computed with filtering (0.01–0.08 Hz) and scaling after preprocessing. fcMRI was performed using a standard seed-based correlation method, and delayed fcMRI (coherence) in frequency domain were also performed between thalamus and cortex.
Results
In comparison with controls, MTBI patients exhibited significantly decreased fALFFs in the thalamus (and frontal/temporal subsegments) and cortical frontal and temporal lobes; as well as decreased thalamo-thalamo and thalamo-frontal/ thalamo-temporal fcMRI at rest based on RS-fMRI (corrected P < 0.05). This thalamic and cortical disruption also existed at task-related condition in patients.
Conclusion
The decreased fALFFs (i.e., lower neuronal activity) in the thalamus and its segments provide additional evidence of thalamic injury in patients with MTBI. Our findings of fALFFs and fcMRI changes during motor task and resting state may offer insights into the underlying cause and primary location of disrupted thalamo-cortical networks after MTBI. J. Magn. Reson. Imaging 2014;39:1558–1568. © 2013 Wiley Periodicals, Inc.
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