Original Research

Rectal cancer: Dynamic contrast-enhanced MRI correlates with lymph node status and epidermal growth factor receptor expression

Corresponding Author

André Lollert MD

Department of Radiology, University of Mainz, Germany

Address reprint requests to: A.L., Department of Radiology, Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany. E-mail: [email protected]Search for more papers by this author

Theodor Junginger MD,

Theodor Junginger MD

Department of General, Abdominal and Transplant Surgery, University of Mainz, Germany

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Carl Christoph Schimanski MD,

Carl Christoph Schimanski MD

1st Medical Department, University of Mainz, Germany

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Stefan Biesterfeld MD,

Stefan Biesterfeld MD

Institute of Pathology, Department of Cytopathology, University of Düsseldorf, Germany

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Ines Gockel MD,

Ines Gockel MD

Department of General, Abdominal and Transplant Surgery, University of Mainz, Germany

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Christoph Düber MD,

Christoph Düber MD

Department of Radiology, University of Mainz, Germany

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Katja Oberholzer MD,

Katja Oberholzer MD

Department of Radiology, University of Mainz, Germany

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André Lollert MD,

Corresponding Author

André Lollert MD

Department of Radiology, University of Mainz, Germany

Address reprint requests to: A.L., Department of Radiology, Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany. E-mail: [email protected]Search for more papers by this author

Theodor Junginger MD,

Theodor Junginger MD

Department of General, Abdominal and Transplant Surgery, University of Mainz, Germany

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Carl Christoph Schimanski MD,

Carl Christoph Schimanski MD

1st Medical Department, University of Mainz, Germany

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Stefan Biesterfeld MD,

Stefan Biesterfeld MD

Institute of Pathology, Department of Cytopathology, University of Düsseldorf, Germany

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Ines Gockel MD,

Ines Gockel MD

Department of General, Abdominal and Transplant Surgery, University of Mainz, Germany

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Christoph Düber MD,

Christoph Düber MD

Department of Radiology, University of Mainz, Germany

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Katja Oberholzer MD,

Katja Oberholzer MD

Department of Radiology, University of Mainz, Germany

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First published: 11 October 2013

https://doi.org/10.1002/jmri.24301

Citations: 28

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Abstract

Purpose

To evaluate correlations between dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and clinicopathologic data as well as immunostaining of the markers of angiogenesis epidermal growth factor receptor (EGFR) and CXC-motif chemokine receptor 4 (CXCR4) in patients with rectal cancer.

Materials and Methods

Presurgical DCE-MRI was performed in 41 patients according to a standardized protocol. Two quantitative parameters (k₂₁, A) were derived from a pharmacokinetic two-compartment model, and one semiquantitative parameter (TTP) was assessed. Standardized surgery and histopathologic examinations were performed in all patients. Immunostaining for EGFR and CXCR4 was performed and evaluated with a standardized scoring system.

Results

DCE-MRI parameter A correlated significantly with the N category (P = 0.048) and k₂₁ with the occurrence of synchronous and metachronous distant metastases (P = 0.029). A trend was shown toward a correlation between k₂₁ and EGFR expression (P = 0.107). A significant correlation was found between DCE-MRI parameter TTP and the expression of EGFR (P = 0.044). DCE-MRI data did not correlate with CXCR4 expression.

Conclusion

DCE-MRI is a noninvasive method which can characterize microcirculation in rectal cancer and correlates with EGFR expression. Given the relationship between the dynamic parameters and the clinicopathologic data, DCE-MRI data may constitute a prognostic indicator for lymph node and distant metastases in patients with rectal cancer. J. Magn. Reson. Imaging 2014;39:1436–1442. © 2013 Wiley Periodicals, Inc.

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Citing Literature

Volume39, Issue6

June 2014

Pages 1436-1442

Rectal cancer: Dynamic contrast-enhanced MRI correlates with lymph node status and epidermal growth factor receptor expression

Abstract

Purpose

Materials and Methods

Results

Conclusion

REFERENCES

Citing Literature

References

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Rectal cancer: Dynamic contrast-enhanced MRI correlates with lymph node status and epidermal growth factor receptor expression

Abstract

Purpose

Materials and Methods

Results

Conclusion

REFERENCES

Citing Literature

References

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