Synthesis and anti-HIV-1 evaluation of 1,5-disubstituted pyrimidine-2,4-diones
Yasser M. Loksha
Nucleic Acid Center Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark
Search for more papers by this authorDaniel Globisch
Nucleic Acid Center Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark
Search for more papers by this authorCorresponding Author
Erik B. Pedersen
Nucleic Acid Center Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark
Nucleic Acid Center Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark Fax: +45 66158780Search for more papers by this authorPaolo La Colla
Dipartimento di Scienze e Tecnologie Biomediche, Sezione di Microbiologia e Virologia Generale e Biotecnologie Microbiche, Universitá di Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy
Search for more papers by this authorGabriella Collu
Dipartimento di Scienze e Tecnologie Biomediche, Sezione di Microbiologia e Virologia Generale e Biotecnologie Microbiche, Universitá di Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy
Search for more papers by this authorRoberta Loddo
Dipartimento di Scienze e Tecnologie Biomediche, Sezione di Microbiologia e Virologia Generale e Biotecnologie Microbiche, Universitá di Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy
Search for more papers by this authorYasser M. Loksha
Nucleic Acid Center Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark
Search for more papers by this authorDaniel Globisch
Nucleic Acid Center Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark
Search for more papers by this authorCorresponding Author
Erik B. Pedersen
Nucleic Acid Center Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark
Nucleic Acid Center Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark Fax: +45 66158780Search for more papers by this authorPaolo La Colla
Dipartimento di Scienze e Tecnologie Biomediche, Sezione di Microbiologia e Virologia Generale e Biotecnologie Microbiche, Universitá di Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy
Search for more papers by this authorGabriella Collu
Dipartimento di Scienze e Tecnologie Biomediche, Sezione di Microbiologia e Virologia Generale e Biotecnologie Microbiche, Universitá di Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy
Search for more papers by this authorRoberta Loddo
Dipartimento di Scienze e Tecnologie Biomediche, Sezione di Microbiologia e Virologia Generale e Biotecnologie Microbiche, Universitá di Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy
Search for more papers by this authorAbstract
1,5-Disubstituted pyrimidine-2,4-diones were synthesized by fusion of 5-bromouracil with an aniline derivative followed by coupling with benzyl halide whereas the opposite synthesis sequence failed. Also 4,6-dichloro-N,N,5-trimethylpyrimidin-2-amine was treated with phenols. The products were tested for their activity against HIV-1.
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