A convenient synthesis of novel 1,3,4-triaryl-3,4-dihydropyrimidin-2(1H)-ones by cyclization of aromatic isocyanates with β-arylamino-1-phenylpropan-1-ones
Yongzhou Hu
ZJU-ENS joint laboratory of medicinal chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, P. R. China
Search for more papers by this authorXiuyang Lu
Department of Chemical and Biochemical Engineering, College of Material Sciences and Chemical Engineering, Zhejiang University
Search for more papers by this authorNa Xue
ZJU-ENS joint laboratory of medicinal chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, P. R. China
Department of Chemical and Biochemical Engineering, College of Material Sciences and Chemical Engineering, Zhejiang University
Search for more papers by this authorYongzhou Hu
ZJU-ENS joint laboratory of medicinal chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, P. R. China
Search for more papers by this authorXiuyang Lu
Department of Chemical and Biochemical Engineering, College of Material Sciences and Chemical Engineering, Zhejiang University
Search for more papers by this authorNa Xue
ZJU-ENS joint laboratory of medicinal chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, P. R. China
Department of Chemical and Biochemical Engineering, College of Material Sciences and Chemical Engineering, Zhejiang University
Search for more papers by this authorAbstract
A simple one-step method for preparation of novel 1,3,4-triaryl-3,4-dihydropyrimidin-2(1H)-ones has been developed by reaction of aromatic isocyanates with β-arylamino-1-phenylpropan-1-ones in refluxing toluene in the presence of KHSO4 and HCl.
References and Notes
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