A convenient preparation of 1,3-disubstituted dihydro-2,4-(1H,3H)pyrimidinediones^†

L. M. Deck,

L. M. Deck

Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131

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E. P. Papadopoulos,

E. P. Papadopoulos

Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131

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L. M. Deck,

L. M. Deck

Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131

Search for more papers by this author

E. P. Papadopoulos,

E. P. Papadopoulos

Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131

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First published: 11 March 2009

https://doi.org/10.1002/jhet.5570370401

Citations: 3

^†

Dedicated to the memory of Professor Raymond N. Castle

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Abstract

The ureas 3 which are obtained from 3-(benzylamino)propanenitrile (1) and various isocyanates (2) cyclize readily upon heating in ethanol, in the presence of hydrochloric acid, to form 3-substituted 1-benzyldihydro-2,4-(1H,3H)pyrimidinediones (11) in good yield.

References and Notes

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Citing Literature

Volume37, Issue4

July/August 2000

Pages 675-680

A convenient preparation of 1,3-disubstituted dihydro-2,4-(1H,3H)pyrimidinediones^†

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A convenient preparation of 1,3-disubstituted dihydro-2,4-(1H,3H)pyrimidinediones†

Abstract

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A convenient preparation of 1,3-disubstituted dihydro-2,4-(1H,3H)pyrimidinediones^†