Green Synthesis of Imidazole Derivatives via Fe₃O₄-MNPs as Reusable Catalyst

In this research, a one-pot, efficient, and high yielding procedure for the synthesis of imidazole derivatives is investigated. The procedure was carried out via multicomponent reaction of isothiocyanate, alkyl bromides, N-methylimidazole, and triphenylphosphine in the presence of magnetic iron oxide nanoparticles (Fe₃O₄-MNPs) as reusable catalyst under solvent-free conditions at 50°C. Also, Fe₃O₄-MNPs were produced using green synthetic method by reduction of ferric chloride solution with Clover Leaf water extract. The nanoparticles generated using this procedure can potentially be important in different purposes such as organic synthesis. Easy, simple, rapid, and clean procedures for the synthesis of imidazole derivatives are the advantages of this study.