An Unprecedented Synthesis of 3,3-Disubstituted Isochroman-1,4-diones Using Nitrones as Oxygen Atom Donors
Vidya Sathi
Department of Chemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram, 695581 Kerala, India
Search for more papers by this authorCorresponding Author
Ani Deepthi
Department of Chemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram, 695581 Kerala, India
E-mail: [email protected]Search for more papers by this authorNoble V. Thomas
Department of Chemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram, 695581 Kerala, India
Search for more papers by this authorVidya Sathi
Department of Chemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram, 695581 Kerala, India
Search for more papers by this authorCorresponding Author
Ani Deepthi
Department of Chemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram, 695581 Kerala, India
E-mail: [email protected]Search for more papers by this authorNoble V. Thomas
Department of Chemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram, 695581 Kerala, India
Search for more papers by this authorAbstract
A one-pot reaction of ninhydrin, N-methyl-C-phenyl nitrone, and secondary amine leading to the unprecedented synthesis of 3,3-disubstituted isochroman-1,4-diones is described here. In this reaction, nitrone acts as an oxygen atom donor producing an imine as a side product. The mild reaction conditions, the flexibility of the secondary amines that can be used, the novelty of the product, and the good yields are the highlights of this reaction.
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