Synthesis and Antimicrobial Activity of New Derivatives of 1,3,4-Thiadiazoles and 1,2,4-Triazoles with 5-Nitroindazole as Support
Corina Cheptea
“Grigore T. Popa” Medicine and Pharmacy University, Faculty of Medical Bioengineering, Department of Biomedical Sciences, 9-13 Kogalniceanu Street, RO-700454 Iasi, Romania
“Al. I. Cuza” University, Faculty of Chemistry, Department of Organic Chemistry, 11 Carol I Blv., RO-700506 Iasi, Romania
Pau et des Pays de l'Adour University, IPREM/EPCP, Helioparc Pau Pyrenees, 2 Avenue P. Angot, 64053 Pau cedex 9, France
Search for more papers by this authorValeriu Sunel
“Grigore T. Popa” Medicine and Pharmacy University, Faculty of Medical Bioengineering, Department of Biomedical Sciences, 9-13 Kogalniceanu Street, RO-700454 Iasi, Romania
Search for more papers by this authorCorresponding Author
Jacques Desbrieres
Pau et des Pays de l'Adour University, IPREM/EPCP, Helioparc Pau Pyrenees, 2 Avenue P. Angot, 64053 Pau cedex 9, France
E-mail: [email protected]Search for more papers by this authorMarcel Popa
“Gheorghe Asachi” Technical University of Iaşi, Faculty of Chemical Engineering and Environmental Protection, 73, Prof.dr.docent Dimitrie Mangeron Bvd, 700050 Iaşi, Romania
Search for more papers by this authorCorina Cheptea
“Grigore T. Popa” Medicine and Pharmacy University, Faculty of Medical Bioengineering, Department of Biomedical Sciences, 9-13 Kogalniceanu Street, RO-700454 Iasi, Romania
“Al. I. Cuza” University, Faculty of Chemistry, Department of Organic Chemistry, 11 Carol I Blv., RO-700506 Iasi, Romania
Pau et des Pays de l'Adour University, IPREM/EPCP, Helioparc Pau Pyrenees, 2 Avenue P. Angot, 64053 Pau cedex 9, France
Search for more papers by this authorValeriu Sunel
“Grigore T. Popa” Medicine and Pharmacy University, Faculty of Medical Bioengineering, Department of Biomedical Sciences, 9-13 Kogalniceanu Street, RO-700454 Iasi, Romania
Search for more papers by this authorCorresponding Author
Jacques Desbrieres
Pau et des Pays de l'Adour University, IPREM/EPCP, Helioparc Pau Pyrenees, 2 Avenue P. Angot, 64053 Pau cedex 9, France
E-mail: [email protected]Search for more papers by this authorMarcel Popa
“Gheorghe Asachi” Technical University of Iaşi, Faculty of Chemical Engineering and Environmental Protection, 73, Prof.dr.docent Dimitrie Mangeron Bvd, 700050 Iaşi, Romania
Search for more papers by this authorAbstract
The synthesis of new derivatives of 1,3,4-thiadiazoles and 1,2,4-triazoles was achieved using the 1,4-disubstituted thiosemicarbazides as intermediaries.
REFERENCES AND NOTES
- 1 Karabasanagaeda, T.; Adhikari, A.; Suchetha, N. Eur J Med Chem 2007, 42, 521.
- 2 Pintilie, O.; Profire, L.; Sunel, V.; Popa, M.; Pui, A. Molecules 2007, 12, 103.
- 3 Mathew, V.; Keshavayya, J.; Vaidya, V.P.; Giles, D. Eur J Med Chem 2007, 42, 823.
- 4 Banday, R.M.; Rauf, A. Chin Chem Lett 2008, 19, 1427.
- 5 Farshori, N.; Banday, R.M.; Ahmad, A.; Khan, U.A.; Rauf, A. Bioorg Med Chem Lett 2010, 20, 1933.
- 6 Padmavathi, V.; Reddy, G.S.; Padmaja, A.; Kondaiah, P.; Shazia, A. Eur J Med Chem 2009, 44, 2106.
- 7 Gӧkșen, S.U.; Kelekci, G.N.; Gӧktaș, O.; Kӧysal, Y.; Kilic, E.; Isik, S.; Aktay, G.; Ozalp, M. Bioorg Med Chem 2007, 15, 5738.
- 8 Zou, X.I.; Lai, L.H.; Jin, G.Y.; Zhang, Z.X. J Agric Food Chem 2002, 50, 3757.
- 9 Amir, M.; Kumar, H.; Javed, S.A. Eur J Med Chem 2008, 43, 2056.
- 10 Xu, J.; Gao, Y.; Zhang, J.; Yu, S.; Zou, Y.; Chai, X.; Wu, Q.; Zhang, D.; Jilang, Y.; Sun, Q. Eur J Med Chem 2011, 46, 3142.
- 11 Foroumadi, A.; Mirzaci, M.; Shafiee, A. Pharmazie 2001, 56, 610.
- 12 Kolovi, G.; Hegde, V.; Khazi, A.; Gadad, P. Bioorg Med Chem 2006, 14, 3069.
- 13 Shenone, S.; Bruno, O.; Ranise, A.; Bondavalli, W.; Falcone, G.; Giordano, L.; Vitelli, M. Bioorg Med Chem 2001, 9, 2149.
- 14 Megeed, A.; Rahman, M.H.; Alkaramany, E.G.; Gendy, A.M. Eur J Med Chem 2009, 44, 117.
- 15 Moise, M.; Sunel, V.; Profire, L.; Popa, M.; Desbrieres, J.; Peptu, C. Molecules 2009, 14, 2621.
- 16 Castro, A.; Castano, T.; Encinas, A.; Porcal, W.; Gil, C. Bioorg Med Chem 2006, 14, 1644.
- 17 Onkol, T.; Cakir, B.; Sahin, M.E. Turk J Chem 2004, 28, 461.
- 18 Cressier, D.; Prouillac, C.; Hernandez, P.; Amourette, C.; Diserbo, M.; Lion, C.; Rima, G. Bioorg Med Chem 2009, 17, 5275.
- 19 Clerici, F.; Pocar, D.; Guido, M.; Lache, A.; Perlini, V.; Brufani, M. J Med Chem 2001, 44, 931.
- 20 Ribeira, M.; Cabral, J.; Cimas, A. J Chem Thermodyn 2010, 42, 1240.
- 21 Berhe, S.; Slupe, A.; Luster, C.; Chartier, H.; Warner, D.; Zalkow, L.; Burgess, E.; Enwerem, N.; Bakare, O. Bioorg Med Chem 2010, 18, 134.
- 22 Rodriguez, J.; Gerpe, A.; Aguirre, G.; Kemmerling, U.; Piro, O.; Aran, V.; Maya, J.; Azar, C.O.; Gonzalez, M.; Cerecetto, H. Eur J Med Chem 2009, 44, 1545.
- 23 Huang, L.; Shih, M.L.; Chen, S.H.; Pan, L.S.; Teng, M.C.; Lee, F.; Kuo, S. Bioorg Med Chem 2006, 14, 528.
- 24 Yakaiah, T.; Ligaiah, V.P.; Naraiah, B.; Shireesha, B.; Kumar, B.; Gururaj, S.; Parthasarathy, T.; Sridhar, B. Bioorg Med Chem Lett 2007, 17, 3445.
- 25 Cheptea, C.; Sunel, V.; Profire, L.; Popa, M.; Lionte, C. Bul Inst Polit Iasi 2009, 55(59), 87.
- 26
Yan, M.;
Chen, Z.;
Zheng, Q. J Chem Res 2003, 5, 618.
10.3184/030823403322655842 Google Scholar
- 27 Oruc, E.; Rollas, S.; Kandemirii, F.; Shvets, N.; Dimoglo, A. J Med Chem 2004, 47, 6760.
- 28 Singh, R.J.; Singh, K.D. Eur J Chem 2010, 7, 37.
- 29 National Committee for Clinical Laboratory Standards. MCCLS Approval Standard Document M2-A7, Villanova, PA, USA, 2000.
