One-Pot Synthesis and Characterization of Some New Types of 5,5′-Disubstituted Bis(imidazolidine-2,4-diones)^†

The synthesis and structural elucidation of some novel 5,5′-disubstituted spiro and nonspiro-bis-hydantoins are reported. The Bucherer Burge's method has been modified for the preparation of some 5,5′-substituted bis(imidazolidine-2,4-dione) derivatives starting with diketones (1–5) and dialdehydes (6, 7). In some cases, diastereoisomeric mixtures of compounds were obtained. The resulting bis-hydantoins (8–11, 13, 14) have not to our knowledge been previously reported in the literature.