The use of β-Thromboglobulin to detect platelet damage by therapeutic ultrasound in vivo
Corresponding Author
Alun R. Williams phD
Department of Medical Biophysics, University of Manchester Medical School, Manchester
ICI Central Toxicology Laboratory, Cheshire
Medical Products Development Department, The Radiochemical Centre, Amersham, Buckinghamshire, England
The Department of Medical Biophysics, University of Manchester Medical School, Stopford Building, Oxford Road, Manchester, EnglandSearch for more papers by this authorBernard V. Chater phD
Department of Medical Biophysics, University of Manchester Medical School, Manchester
ICI Central Toxicology Laboratory, Cheshire
Medical Products Development Department, The Radiochemical Centre, Amersham, Buckinghamshire, England
Search for more papers by this authorKenneth A. Allen BSc
Department of Medical Biophysics, University of Manchester Medical School, Manchester
ICI Central Toxicology Laboratory, Cheshire
Medical Products Development Department, The Radiochemical Centre, Amersham, Buckinghamshire, England
Search for more papers by this authorJoel H. Sanderson MB, ChB
Department of Medical Biophysics, University of Manchester Medical School, Manchester
ICI Central Toxicology Laboratory, Cheshire
Medical Products Development Department, The Radiochemical Centre, Amersham, Buckinghamshire, England
Search for more papers by this authorCorresponding Author
Alun R. Williams phD
Department of Medical Biophysics, University of Manchester Medical School, Manchester
ICI Central Toxicology Laboratory, Cheshire
Medical Products Development Department, The Radiochemical Centre, Amersham, Buckinghamshire, England
The Department of Medical Biophysics, University of Manchester Medical School, Stopford Building, Oxford Road, Manchester, EnglandSearch for more papers by this authorBernard V. Chater phD
Department of Medical Biophysics, University of Manchester Medical School, Manchester
ICI Central Toxicology Laboratory, Cheshire
Medical Products Development Department, The Radiochemical Centre, Amersham, Buckinghamshire, England
Search for more papers by this authorKenneth A. Allen BSc
Department of Medical Biophysics, University of Manchester Medical School, Manchester
ICI Central Toxicology Laboratory, Cheshire
Medical Products Development Department, The Radiochemical Centre, Amersham, Buckinghamshire, England
Search for more papers by this authorJoel H. Sanderson MB, ChB
Department of Medical Biophysics, University of Manchester Medical School, Manchester
ICI Central Toxicology Laboratory, Cheshire
Medical Products Development Department, The Radiochemical Centre, Amersham, Buckinghamshire, England
Search for more papers by this authorAbstract
Three sequential blood samples were drawn from arms of adult human volunteers by means of a cannula technique, and the plasma levels of β-thromboglobulin (β-TG, an index of platelet damage) were measured. Ultrasound (0.75 MHz, continuous wave; spatially averaged intensity 0.34 to 0.5 W/cm–2) was applied to the blood vessels while the second sample of each series was being taken. No elevation of β-TG was detected, indicating that under these conditions ultrasonic irradiation had not damaged an appreciable number of platelets. There was, however, an indication of decreased platelet sensitivity following insonation; and it is postulated that this may be the result of either increased production or secretion of the potent endothelial platelet inhibitor, prostacyclin, or both.
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