Evaluation of Antimicrobial Activity of Some Newly Synthesized 4-Thiazolidinones
Nabil Abdul-kader Saleh
Chemistry Department, Faculty of Science, Tripoli University, Tripoli, Libya
Search for more papers by this authorHussein El-abd Saltani
Chemistry Department, Faculty of Science, Tripoli University, Tripoli, Libya
Search for more papers by this authorCorresponding Author
Fadhil Abbas Al-Issa
Chemistry Department, Faculty of Science, Tripoli University, Tripoli, Libya
Chemistry Department, Faculty of Science, Tripoli University, Tripoli, Libya, Mobile: +218 924042939Search for more papers by this authorAl-Sadek Gomaa Melad
Chemistry Department, Faculty of Education (Kasr Ben-Ghashier), Tripoli University, Tripoli, Libya
Search for more papers by this authorNabil Abdul-kader Saleh
Chemistry Department, Faculty of Science, Tripoli University, Tripoli, Libya
Search for more papers by this authorHussein El-abd Saltani
Chemistry Department, Faculty of Science, Tripoli University, Tripoli, Libya
Search for more papers by this authorCorresponding Author
Fadhil Abbas Al-Issa
Chemistry Department, Faculty of Science, Tripoli University, Tripoli, Libya
Chemistry Department, Faculty of Science, Tripoli University, Tripoli, Libya, Mobile: +218 924042939Search for more papers by this authorAl-Sadek Gomaa Melad
Chemistry Department, Faculty of Education (Kasr Ben-Ghashier), Tripoli University, Tripoli, Libya
Search for more papers by this authorAbstract
The antimicrobial activity of thirteen newly synthesized 4-thiazolidinones (TZONs) and four dithiolane derivatives was assessed against susceptible and resistant bacteria, including MRSA, as well as Candida albicans. The structure-activity relationships revealed that 4-Thiazolidinone derivatives harboring p-chlorophenyl and dicarboxyethyl at the 2-ethenyl and 5-arylidine positions of the thiazolidinone ring display considerable antibacterial properties. No antifungal activity was recorded by all tested compounds against Candida albicans. The possible potentiative (synergistic) effect of the most active compounds to a few commercial antibiotics was also investigated.
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