Review Article
A mini-review: Cell response to microscale, nanoscale, and hierarchical patterning of surface structure
HoJun Jeon,
Carl G. Simon Jr,
GeunHyung Kim,
HoJun Jeon
Department of Bio-Mechatronic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, South Korea
Search for more papers by this authorCorresponding Author
Carl G. Simon Jr
Biosystems and Biomaterials Division, National Institute of Standards and Technology, Gaithersburg, Maryland
Correspondence to: C.G. Simon (e-mail: [email protected]) and G.H. Kim (e-mail: [email protected])Search for more papers by this authorCorresponding Author
GeunHyung Kim
Department of Bio-Mechatronic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, South Korea
Correspondence to: C.G. Simon (e-mail: [email protected]) and G.H. Kim (e-mail: [email protected])Search for more papers by this authorHoJun Jeon,
Carl G. Simon Jr,
GeunHyung Kim,
HoJun Jeon
Department of Bio-Mechatronic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, South Korea
Search for more papers by this authorCorresponding Author
Carl G. Simon Jr
Biosystems and Biomaterials Division, National Institute of Standards and Technology, Gaithersburg, Maryland
Correspondence to: C.G. Simon (e-mail: [email protected]) and G.H. Kim (e-mail: [email protected])Search for more papers by this authorCorresponding Author
GeunHyung Kim
Department of Bio-Mechatronic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, South Korea
Correspondence to: C.G. Simon (e-mail: [email protected]) and G.H. Kim (e-mail: [email protected])Search for more papers by this authorAbstract
Cellular behavior can be influenced by the chemical and physical surface characteristics of biomedical substrates. To understand the relationships between various topographical surface patterns and cellular activities, various types of pattern models have been developed and examined in a range of sizes (microscale, nanoscale, and hierarchical structures consisting of both) and shapes (pillar, hole, groove, grate, grid, and island). Here, we review fabrication methods for obtaining physically patterned microscale and nanoscale surfaces, and discuss the relationships between cellular responses and physically patterned surfaces, which could be applied to various biomedical scaffolds used in tissue engineering applications. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1580–1594, 2014.
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