Volume 95B, Issue 2 pp. 269-275
THIS ARTICLE HAS BEEN RETRACTED

Retracted: Bone healing in critical-size defects treated with new bioactive glass/calcium sulfate: A histologic and histometric study in rat calvaria

Maria J. H. Nagata

Corresponding Author

Maria J. H. Nagata

Division of Periodontics, Department of Surgery and Integrated Clinic, Dental School of Araçatuba, São Paulo State University-UNESP, Brazil

Division of Periodontics, Department of Surgery and Integrated Clinic, Dental School of Araçatuba, São Paulo State University - UNESP, BrazilSearch for more papers by this author
Flávia A. C. Furlaneto

Flávia A. C. Furlaneto

Division of Periodontics, Department of Surgery and Integrated Clinic, Dental School of Araçatuba, São Paulo State University-UNESP, Brazil

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Antonio J. Moretti

Antonio J. Moretti

Department of Periodontology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

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Jerry E. Bouquot

Jerry E. Bouquot

Department of Diagnostic Sciences, The University of Texas Health Science Center Dental Branch, Houston, Texas

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Chul W. Ahn

Chul W. Ahn

Department of Clinical Sciences, The University of Texas Southwestern Medical Center, Dallas, Texas

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Michel R. Messora

Michel R. Messora

Division of Periodontics, Department of Surgery and Integrated Clinic, Dental School of Araçatuba, São Paulo State University-UNESP, Brazil

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Stephen E. Fucini

Stephen E. Fucini

Division of Periodontics, Department of Surgery and Integrated Clinic, Dental School of Araçatuba, São Paulo State University-UNESP, Brazil

Private Practice, Hanover, New Hampshire

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Valdir G. Garcia

Valdir G. Garcia

Division of Periodontics, Department of Surgery and Integrated Clinic, Dental School of Araçatuba, São Paulo State University-UNESP, Brazil

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Alvaro F. Bosco

Alvaro F. Bosco

Division of Periodontics, Department of Surgery and Integrated Clinic, Dental School of Araçatuba, São Paulo State University-UNESP, Brazil

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First published: 22 September 2010
Citations: 19

Abstract

This study analyzed histologically the influence of new spherical bioactive glass (NBG) particles with or without a calcium sulfate (CS) barrier on bone healing in surgically created critical-size defects (CSD) in rat calvaria. A CSD was made in each calvarium of 60 rats, which were divided into three groups: C (control): the defect was filled with blood clot only; NBG: the defect was filled with NBG only; and NBG/CS: the defect was filled with NBG covered by CS barrier. Subgroups were euthanized at 4 or 12 weeks. Amounts of new bone and remnants of implanted materials were calculated as percentages of total area of the original defect. Data were statistically analyzed. In contrast to Group C, thickness throughout defects in Groups NBG and NBG/CS was similar to the original calvarium. At 4 weeks, Group C had significantly more bone formation than Group NBG/CS. No significant differences were found between Group NBG and either Group C or Group NBG/CS. At 12 weeks, Group C had significantly more bone formation than Group NBG or NBG/CS. NBG particles, used with or without a CS barrier, maintained volume and contour of area grafted in CSD. Presence of remaining NBG particles might have accounted for smaller amount of new bone in Groups NBG and NBG/CS at 12 weeks post-operative. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010.

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