Thermo-responsive hydrogels from cellulose-based polyelectrolytes and catanionic vesicles for biomedical application
Gesmi Milcovich
Department of Chemical and Pharmaceutical Sciences, University of Trieste, via L. Giorgieri 1, Trieste, I-34127 Italy
Search for more papers by this authorFilipe Antunes
Chemistry Department, University of Coimbra, Coimbra, 3004-535 Portugal
Search for more papers by this authorSamuel Golob
Department of Chemical and Pharmaceutical Sciences, University of Trieste, P.le Europa, 1, Trieste, I-34127 Italy
Search for more papers by this authorRossella Farra
Department of Engineering and Architecture, University of Trieste, Trieste, I-34127 Italy
Search for more papers by this authorCorresponding Author
Mario Grassi
Department of Engineering and Architecture, University of Trieste, Trieste, I-34127 Italy
Correspondence to. Mario Grassi; e-mail: [email protected]Search for more papers by this authorDario Voinovich
Department of Chemical and Pharmaceutical Sciences, University of Trieste, P.le Europa, 1, Trieste, I-34127 Italy
Search for more papers by this authorGabriele Grassi
Department of Life Sciences, University Hospital of Cattinara, Trieste, 34100 Italy
Search for more papers by this authorFioretta Asaro
Department of Chemical and Pharmaceutical Sciences, University of Trieste, via L. Giorgieri 1, Trieste, I-34127 Italy
Search for more papers by this authorGesmi Milcovich
Department of Chemical and Pharmaceutical Sciences, University of Trieste, via L. Giorgieri 1, Trieste, I-34127 Italy
Search for more papers by this authorFilipe Antunes
Chemistry Department, University of Coimbra, Coimbra, 3004-535 Portugal
Search for more papers by this authorSamuel Golob
Department of Chemical and Pharmaceutical Sciences, University of Trieste, P.le Europa, 1, Trieste, I-34127 Italy
Search for more papers by this authorRossella Farra
Department of Engineering and Architecture, University of Trieste, Trieste, I-34127 Italy
Search for more papers by this authorCorresponding Author
Mario Grassi
Department of Engineering and Architecture, University of Trieste, Trieste, I-34127 Italy
Correspondence to. Mario Grassi; e-mail: [email protected]Search for more papers by this authorDario Voinovich
Department of Chemical and Pharmaceutical Sciences, University of Trieste, P.le Europa, 1, Trieste, I-34127 Italy
Search for more papers by this authorGabriele Grassi
Department of Life Sciences, University Hospital of Cattinara, Trieste, 34100 Italy
Search for more papers by this authorFioretta Asaro
Department of Chemical and Pharmaceutical Sciences, University of Trieste, via L. Giorgieri 1, Trieste, I-34127 Italy
Search for more papers by this authorAbstract
In this study, negatively charged catanionic vesicles/hydrophobically modified hydroxyethylcellulose polymers thermo-responsive hydrogels have been fabricated. Vesicular aggregates were found to act as multifunctional junctions for networking of modified-cellulose water solutions. The contributions of the electrostatic and hydrophobic interactions were evaluated by changing either vesicles composition or the polymer hydrophobic substitution. Thermal-induced size and lamellarity of hydrogel-enclosed vesicles were detected, with further polygonal shape changes induced by cellulose-based polymer addition. The thermal transition was also found to tune hydrogel mechanical behaviour. The network formation was further assessed through molecular insights, which allow to determine the arrangement of the polymer chains on the vesicles' surface. The examined systems exhibited interesting thermo-responsive characteristics. Thus, vesicularly cross-linked hydrogels herein presented can offer a wide variety of applications, i.e. in biomedical field, as multi-drug delivery systems, thanks to their ability to provide for different environments to guest molecules, comprising bulk water, vesicles' interior and bilayers, sites on polymeric chains. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1668–1679, 2016.
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