The application of Fe3O4 nanoparticles in cancer research: A new strategy to inhibit drug resistance
Corresponding Author
Xuemei Wang
State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, People's Republic of China
Xuemei Wang, State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, People's Republic of China
Baoan Chen, School of Clinic Medical, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorRenyun Zhang
State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorChunhui Wu
State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorYongyuan Dai
School of Clinic Medical, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorMin Song
State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorSebastian Gutmann
Institute of Pure and Applied Chemistry, School of Mathematics and Natural Sciences, Carl von Ossietzky University Oldenburg, D-26111 Oldenburg, Germany
Search for more papers by this authorFeng Gao
School of Clinic Medical, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorGang Lv
State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorJingyuan Li
State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorXiaomao Li
Department of Physics, University of Saarland, D-66041 Saarbruecken, Germany
Search for more papers by this authorZhiqun Guan
Department of Physics, University of Saarland, D-66041 Saarbruecken, Germany
Search for more papers by this authorDegang Fu
State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorCorresponding Author
Baoan Chen
School of Clinic Medical, Southeast University, Nanjing 210096, People's Republic of China
Xuemei Wang, State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, People's Republic of China
Baoan Chen, School of Clinic Medical, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorCorresponding Author
Xuemei Wang
State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, People's Republic of China
Xuemei Wang, State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, People's Republic of China
Baoan Chen, School of Clinic Medical, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorRenyun Zhang
State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorChunhui Wu
State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorYongyuan Dai
School of Clinic Medical, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorMin Song
State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorSebastian Gutmann
Institute of Pure and Applied Chemistry, School of Mathematics and Natural Sciences, Carl von Ossietzky University Oldenburg, D-26111 Oldenburg, Germany
Search for more papers by this authorFeng Gao
School of Clinic Medical, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorGang Lv
State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorJingyuan Li
State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorXiaomao Li
Department of Physics, University of Saarland, D-66041 Saarbruecken, Germany
Search for more papers by this authorZhiqun Guan
Department of Physics, University of Saarland, D-66041 Saarbruecken, Germany
Search for more papers by this authorDegang Fu
State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorCorresponding Author
Baoan Chen
School of Clinic Medical, Southeast University, Nanjing 210096, People's Republic of China
Xuemei Wang, State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, People's Republic of China
Baoan Chen, School of Clinic Medical, Southeast University, Nanjing 210096, People's Republic of China
Search for more papers by this authorAbstract
Although much effort has been extended to the efficient cancer therapies, the drug resistance is still a major obstacle in cancer chemotherapeutic treatments. Almost 90% of the cancer therapy failure is caused by the relative problems. Recently, the application of drug coated polymer nanospheres and nanoparticles to inhibit the related drug resistance has attracted much attention. In this report, we have explored a novel strategy to inhibit the multidrug resistance of the targeted tumor cells by combining the unique properties of tetraheptylammonium capped Fe3O4 magnetic nanoparticles with the drug accumulation of anticancer drug daunorubicin. Our results of confocal fluorescence and atomic force microscopy (AFM) as well as electrochemical studies demonstrate the remarkable synergistic effect of Fe3O4 nanoparticles on drug uptake of daunorubicin in leukemia K562 cells. These observations indicate that the interaction between the magnetic nanoparticles Fe3O4 and biologically active molecules on the membrane of leukemia cell lines may contribute to their beneficial effect on cellular uptake so that the synergistic enhanced effect of magnetic nanoparticles Fe3O4 on drug uptake of drug resistance leukemia K562 cells could be observed upon application of the Fe3O4 nanoparticles. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006
Supporting Information
This article contains supplementary material available via the Internet at http://www.interscience.wiley.com/jpages/1549-3296/suppmat .
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| jws-jbm.a.30901.fig.TIF429.4 KB | Supporting Information file jws-jbm.a.30901.fig.TIF |
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