The nature and dissemination of UHMWPE wear debris retrieved from periprosthetic tissue of THR
Alistair P. D. Elfick,
Sarah M. Green,
Steve Krikler,
Anthony Unsworth,
Corresponding Author
Alistair P. D. Elfick
Centre for Biomedical Engineering, University of Durham, South Road, Durham, DH1 3LE, United Kingdom
Centre for Biomedical Engineering, University of Durham, South Road, Durham, DH1 3LE, United KingdomSearch for more papers by this authorSarah M. Green
Centre for Biomedical Engineering, University of Durham, South Road, Durham, DH1 3LE, United Kingdom
Search for more papers by this authorSteve Krikler
University Hospitals Coventry and Warwick NHS Trust, Stoney Stanton Road, Coventry, CV1 4FH, United Kingdom
Search for more papers by this authorAnthony Unsworth
Centre for Biomedical Engineering, University of Durham, South Road, Durham, DH1 3LE, United Kingdom
Search for more papers by this authorAlistair P. D. Elfick,
Sarah M. Green,
Steve Krikler,
Anthony Unsworth,
Corresponding Author
Alistair P. D. Elfick
Centre for Biomedical Engineering, University of Durham, South Road, Durham, DH1 3LE, United Kingdom
Centre for Biomedical Engineering, University of Durham, South Road, Durham, DH1 3LE, United KingdomSearch for more papers by this authorSarah M. Green
Centre for Biomedical Engineering, University of Durham, South Road, Durham, DH1 3LE, United Kingdom
Search for more papers by this authorSteve Krikler
University Hospitals Coventry and Warwick NHS Trust, Stoney Stanton Road, Coventry, CV1 4FH, United Kingdom
Search for more papers by this authorAnthony Unsworth
Centre for Biomedical Engineering, University of Durham, South Road, Durham, DH1 3LE, United Kingdom
Search for more papers by this authorAbstract
The role of wear debris in provoking joint replacement failure through bone resorption is now supported by much research. This study presents the analysis of 104 tissue samples using laser diffraction wear particle analysis in conjunction with standard histologic methods. The number and volume distributions were correlated to a range of joint and patient parameters. The median particle diameter by number was 0.69 μm. No particles smaller than 0.113 μm were resolved. No variation in terms of particle distribution was found among joint types. The ability of particles to migrate away from their point of origin was found to be inversely proportional to their size. The numbers of particles per gram of tissue found in various regions around the prosthesis varied little. Further, the numbers of particles in tissue samples shown to have a chronic foreign-body reaction was > 1 × 109 particles/gram. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 65A: 95–108, 2003
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