Hibernoma in the renal sinus: A case mimicking malignancy
Ayano Kashima
Department of Urology, Aichi Medical University, Nagakute, Aichi, Japan
Contribution: Conceptualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorCorresponding Author
Tsuyoshi Majima
Department of Urology, Aichi Medical University, Nagakute, Aichi, Japan
Correspondence: Tsuyoshi Majima M.D., Ph.D., Department of Urology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan. Email: [email protected]
Contribution: Conceptualization, Supervision, Writing - original draft, Writing - review & editing
Search for more papers by this authorTomoaki Muramatsu
Department of Urology, Aichi Medical University, Nagakute, Aichi, Japan
Contribution: Conceptualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorHaruka Kurosu
Department of Urology, Aichi Medical University, Nagakute, Aichi, Japan
Contribution: Conceptualization
Search for more papers by this authorHideji Kawanishi
Department of Urology, Aichi Medical University, Nagakute, Aichi, Japan
Contribution: Conceptualization
Search for more papers by this authorIkuo Kobayashi
Department of Urology, Aichi Medical University, Nagakute, Aichi, Japan
Contribution: Conceptualization
Search for more papers by this authorKeishi Kajikawa
Department of Urology, Aichi Medical University, Nagakute, Aichi, Japan
Contribution: Conceptualization
Search for more papers by this authorTaishi Takahara
Department of Surgical Pathology, Aichi Medical University, Nagakute, Aichi, Japan
Contribution: Data curation
Search for more papers by this authorTakahiro Yamamoto
Department of Radiology, Aichi Medical University, Nagakute, Aichi, Japan
Contribution: Data curation
Search for more papers by this authorNaoto Sassa
Department of Urology, Aichi Medical University, Nagakute, Aichi, Japan
Contribution: Supervision
Search for more papers by this authorAyano Kashima
Department of Urology, Aichi Medical University, Nagakute, Aichi, Japan
Contribution: Conceptualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorCorresponding Author
Tsuyoshi Majima
Department of Urology, Aichi Medical University, Nagakute, Aichi, Japan
Correspondence: Tsuyoshi Majima M.D., Ph.D., Department of Urology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan. Email: [email protected]
Contribution: Conceptualization, Supervision, Writing - original draft, Writing - review & editing
Search for more papers by this authorTomoaki Muramatsu
Department of Urology, Aichi Medical University, Nagakute, Aichi, Japan
Contribution: Conceptualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorHaruka Kurosu
Department of Urology, Aichi Medical University, Nagakute, Aichi, Japan
Contribution: Conceptualization
Search for more papers by this authorHideji Kawanishi
Department of Urology, Aichi Medical University, Nagakute, Aichi, Japan
Contribution: Conceptualization
Search for more papers by this authorIkuo Kobayashi
Department of Urology, Aichi Medical University, Nagakute, Aichi, Japan
Contribution: Conceptualization
Search for more papers by this authorKeishi Kajikawa
Department of Urology, Aichi Medical University, Nagakute, Aichi, Japan
Contribution: Conceptualization
Search for more papers by this authorTaishi Takahara
Department of Surgical Pathology, Aichi Medical University, Nagakute, Aichi, Japan
Contribution: Data curation
Search for more papers by this authorTakahiro Yamamoto
Department of Radiology, Aichi Medical University, Nagakute, Aichi, Japan
Contribution: Data curation
Search for more papers by this authorNaoto Sassa
Department of Urology, Aichi Medical University, Nagakute, Aichi, Japan
Contribution: Supervision
Search for more papers by this authorAbstract
Introduction
Hibernomas are benign tumors of brown adipose tissue. Hibernoma in the renal sinus is extremely rare. Herein, we present the third known case of renal hibernoma.
Case presentation
A 71-year-old man reported to our department with a left kidney tumor with an average growth rate of 5 mm/year and a progressive contrast effect on computed tomography. It was diagnosed as a hibernoma following a laparoscopic radical nephrectomy.
Conclusion
We encountered a rare case of a hibernoma in the renal sinus. Development of new and accurate diagnostic methods for hibernoma, without resorting to nephrectomy, is essential.
Conflict of interest
The authors declare no conflicts of interest.
References
- 1Merkel H. On a pseudolipoma of the breast (peculiar fat tumor). Beitr. Pathol. Anat. 1906; 39: 152–157.
- 2Ahn C, Harvey JC. Mediastinal hibernoma, a rare tumor. Ann. Thorac. Surg. 1990; 50: 828–830.
- 3Streich L, Yang X. Hibernoma with inflammatory features: a description of a new variant. Hum. Pathol. Case Rep. 2020; 22: 200429.
10.1016/j.ehpc.2020.200429 Google Scholar
- 4Larkin K, Chua KJ, Doppalapudi SK et al. Inflammatory hibernoma of the renal hilum mimicking a renal pelvis tumor. J. Kidney Cancer VHL 2022; 9: 48–50.
- 5Furlong MA, Fanburg-Smith JC, Miettinen M. The morphologic spectrum of hibernoma: a clinicopathologic study of 170 cases. Am. J. Surg. Pathol. 2001; 25: 809–814.
- 6Lidell ME. Brow adipose tissue in human infants. Handb. Exp. Pharmacol. 2019; 251: 107–123.
- 7Nord KH, Magnusson L, Isaksson M et al. Concomitant deletions of tumor suppressor genes MEN1 and AIP are essential for the pathogenesis of the brown fat tumor hibernoma. Proc. Natl. Acad. Sci. USA 2010; 107: 21122–22112.
- 8Li X-S, Yao L, Gong K et al. Growth pattern of renal cell carcinoma (RCC) in patients with delayed surgical intervention. J. Cancer Res. Clin. Oncol. 2012; 138: 269–274.
- 9Chawla SN, Crispen PL, Hanlon AL, Greenberg RE, Chen DYT, Uzzo RG. The natural history of observed enhancing renal masses: meta-analysis and review of the world literature. J. Urol. 2006; 175: 425–431.
- 10Pierorazio PM, Hyams ES, Tsai S et al. Multiphasic enhancement patterns of small renal masses (≤4 cm) on preoperative computed tomography: utility for distinguishing subtypes of renal cell carcinoma, angiomyolipoma, and oncocytoma. Urology 2013; 81: 1265–1271.
- 11Lazar MA. Developmental biology. How now, brown fat? Science 2008; 321: 1048–1049.
- 12Donato R, R cannon B, Sorci G et al. Function of S100 proteins. Curr. Mol. Med. 2013; 13: 24–57.
- 13Malzahn J, Kastrenopoulou A, Papadimitriou-Olivgeri I et al. Immunophenotypic expression of UCP1 in hibernoma and other adipose/non adipose soft tissue tumours. Clin. Sarcoma Res. 2019; 9: 8.
- 14Saito M, Okamatsu-Ogura Y, Matsushita M et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 2009; 58: 1526–1531.
- 15Seki T, Yang Y, Sun X et al. Brown-fat-mediated tumour suppression by cold-altered global metabolism. Nature 2022; 608: 421–428.
- 16Burt AM, Huang BK. Imaging review of lipomatous musculoskeletal lesions. Sicot J. 2017; 3: 34.
- 17Park JH, Ogura K, Fujiwara T et al. The values and limitations of FDG-PET/CT for diagnosis of hibernoma. Case Rep. Orthop. 2015; 2015: 958690.