Adherence to WCRF/AICR cancer prevention recommendations and metabolic syndrome in breast cancer patients
Corresponding Author
Eleonora Bruno
Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy
Correspondence to: Eleonora Bruno, Epidemiology & Prevention Unit, Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori Via Venezian, 1 20133 Milano, Italy, Tel.: +390223903512, Fax: + 390223903516, E-mail: [email protected]Search for more papers by this authorGiuliana Gargano
Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy
Search for more papers by this authorAnna Villarini
Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy
Search for more papers by this authorAdele Traina
Department of Oncology, A.R.N.A.S Ospedali Civico E Benfratelli G. Di Cristina E M. Ascoli, Palermo, Italy
Search for more papers by this authorHarriet Johansson
Division of Chemoprevention and Genetics, European Institute Of Oncology, Milan, Italy
Search for more papers by this authorMaria Piera Mano
Dipartimento Scienze Chirurgiche, Study University, Turin, Italy
S.C. Epidemiologia Dei Tumori, AOU Città Della Salute E Della Scienza, CPO Piemonte, Turin, Italy
Search for more papers by this authorMaria Santucci De Magistris
Azienda Ospedaliera Unversitaria, Federico II, Naples, Italy
Search for more papers by this authorMilena Simeoni
Associazione LUMEN, San Pietro In Cerro (Piacenza), Italy
Search for more papers by this authorMaggiorino Barbero
Obstetrics and Gynecology Unit, Cardinal Massaia Hospital, Asti, Italy
Search for more papers by this authorRocco Galasso
Biostatistics and Cancer Registry, Unit Of Clinical Epidemiology, IRCCS Centro Di Riferimento Oncologico Di Basilicata, Rionero In Vulture (Potenza), Italy
Search for more papers by this authorMaurizio Zarcone
Department of Oncology, A.R.N.A.S Ospedali Civico E Benfratelli G. Di Cristina E M. Ascoli, Palermo, Italy
Search for more papers by this authorEmanuela Zagallo
Division of Chemoprevention and Genetics, European Institute Of Oncology, Milan, Italy
Search for more papers by this authorElisabetta Venturelli
Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy
Search for more papers by this authorManuela Bellegotti
Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy
Search for more papers by this authorFranco Berrino
Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy
Search for more papers by this authorPatrizia Pasanisi
Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy
Search for more papers by this authorCorresponding Author
Eleonora Bruno
Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy
Correspondence to: Eleonora Bruno, Epidemiology & Prevention Unit, Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori Via Venezian, 1 20133 Milano, Italy, Tel.: +390223903512, Fax: + 390223903516, E-mail: [email protected]Search for more papers by this authorGiuliana Gargano
Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy
Search for more papers by this authorAnna Villarini
Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy
Search for more papers by this authorAdele Traina
Department of Oncology, A.R.N.A.S Ospedali Civico E Benfratelli G. Di Cristina E M. Ascoli, Palermo, Italy
Search for more papers by this authorHarriet Johansson
Division of Chemoprevention and Genetics, European Institute Of Oncology, Milan, Italy
Search for more papers by this authorMaria Piera Mano
Dipartimento Scienze Chirurgiche, Study University, Turin, Italy
S.C. Epidemiologia Dei Tumori, AOU Città Della Salute E Della Scienza, CPO Piemonte, Turin, Italy
Search for more papers by this authorMaria Santucci De Magistris
Azienda Ospedaliera Unversitaria, Federico II, Naples, Italy
Search for more papers by this authorMilena Simeoni
Associazione LUMEN, San Pietro In Cerro (Piacenza), Italy
Search for more papers by this authorMaggiorino Barbero
Obstetrics and Gynecology Unit, Cardinal Massaia Hospital, Asti, Italy
Search for more papers by this authorRocco Galasso
Biostatistics and Cancer Registry, Unit Of Clinical Epidemiology, IRCCS Centro Di Riferimento Oncologico Di Basilicata, Rionero In Vulture (Potenza), Italy
Search for more papers by this authorMaurizio Zarcone
Department of Oncology, A.R.N.A.S Ospedali Civico E Benfratelli G. Di Cristina E M. Ascoli, Palermo, Italy
Search for more papers by this authorEmanuela Zagallo
Division of Chemoprevention and Genetics, European Institute Of Oncology, Milan, Italy
Search for more papers by this authorElisabetta Venturelli
Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy
Search for more papers by this authorManuela Bellegotti
Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy
Search for more papers by this authorFranco Berrino
Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy
Search for more papers by this authorPatrizia Pasanisi
Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy
Search for more papers by this authorConflict of Interest: All Authors declare no conflicts of interest.
Abstract
Metabolic syndrome (MetS), conventionally defined by the presence of at least three out of five dismetabolic traits (abdominal obesity, hypertension, low plasma HDL-cholesterol and high plasma glucose and triglycerides), has been associated with both breast cancer (BC) incidence and prognosis. We investigated the association between the prevalence of MetS and a score of adherence to the World Cancer Research Fund (WCRF) and American Institute for Cancer Research (AICR) recommendations for the prevention of cancer in a cross-sectional study of BC patients. The DIet and ANdrogen-5study (DIANA-5) for the prevention of BC recurrences recruited 2092 early stage BC survivors aged 35–70. At recruitment, all women completed a 24-hour food frequency and physical activity diary on their consumption and activity of the previous day. Using these diaries we created a score of adherence to five relevant WCRF/AICR recommendations. The prevalence ratios (PRs) and 95% confidence intervals (CIs) of MetS associated with the number of recommendations met were estimated using a binomial regression model. The adjusted PRs of MetS decreased with increasing number of recommendations met (p < 0.001). Meeting all the five recommendations versus meeting none or only one was significantly associated with a 57% lower MetS prevalence (95% CI 0.35–0.73). Our results suggest that adherence to WCRF/AICR recommendations is a major determinant of MetS and may have a clinical impact.
Abstract
What's new?
Postmenopausal women with metabolic syndrome (MetS) are at increased risk of breast cancer (BC), as well as poorer prognosis and possibly recurrence. In this study, the authors found that women who adhered to more dietary recommendations for preventing cancer were also less likely to develop MetS. These results warrant further study, as they suggest that following dietary guidelines that reduce MetS might, in turn, reduce the risk of BC and BC recurrence.
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