Experimental Cancer
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Plant-derived diterpene esters enhance HTLV-I-induced colony formation of lymphocytes in co-culture
Shuichi Matsuda,
Yoshinobu Nakao,
Hajime Ohigashi,
Koichi Koshimizu,
Yohei Ito,
Shuichi Matsuda
The Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650
Search for more papers by this authorCorresponding Author
Yoshinobu Nakao
The Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650
The Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650Search for more papers by this authorHajime Ohigashi
Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606
Search for more papers by this authorKoichi Koshimizu
Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606
Search for more papers by this authorYohei Ito
Department of Microbiology, Faculty of Medicine, Kyoto University, Kyoto 606, Japan
Died on July 26, 1985.
Search for more papers by this authorShuichi Matsuda,
Yoshinobu Nakao,
Hajime Ohigashi,
Koichi Koshimizu,
Yohei Ito,
Shuichi Matsuda
The Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650
Search for more papers by this authorCorresponding Author
Yoshinobu Nakao
The Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650
The Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650Search for more papers by this authorHajime Ohigashi
Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606
Search for more papers by this authorKoichi Koshimizu
Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606
Search for more papers by this authorYohei Ito
Department of Microbiology, Faculty of Medicine, Kyoto University, Kyoto 606, Japan
Died on July 26, 1985.
Search for more papers by this authorAbstract
The addition to culture dishes of 10–50 ng/ml of the essential diterpene ester of Sapium sebiferum, 12-O-hexadecanoylphorbol-13-acetate (HPA), increased colony formation of normal peripheral blood lymphocytes co-cultured with γ-irradiated HTLV-1-producing HUT102 cells. The cells in the stimulated colonies showed an approximately 3-fold increase in the expression of interleukin-2 (IL-2) receptors and a 1.5-to 2.0-fold increase in human T-lymphotropic virus type-I (HTLV-I) p19-positive cells. This biological potency was analogous to that induced by the most potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and stronger than that of 12-O-hexade-canoyl-16-hydroxyphorbol-13-acetate (HHPA) isolated from Aleurites fordii.
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