Tumour-promoting effect of chilli extract in BALB/c mice
R. C. Agrawal
Carcinogenesis Division, Cancer Research Institute, Tata Memorial Centre, Parel, Bombay 400 012, India
Search for more papers by this authorM. Wiessler
Institute for Toxicology and Chemotherapy, German Cancer Research Centre, D-6900 Heidelberg
Search for more papers by this authorE. Hecker
Institute for Biochemistry, German Cancer Research Centre, D-6900 Heidelberg, FRG
Search for more papers by this authorCorresponding Author
S. V. Bhide
Carcinogenesis Division, Cancer Research Institute, Tata Memorial Centre, Parel, Bombay 400 012, India
Carcinogenesis Division, Cancer Research Institute, Tata Memorial Centre, Parel, Bombay 400 012, IndiaSearch for more papers by this authorR. C. Agrawal
Carcinogenesis Division, Cancer Research Institute, Tata Memorial Centre, Parel, Bombay 400 012, India
Search for more papers by this authorM. Wiessler
Institute for Toxicology and Chemotherapy, German Cancer Research Centre, D-6900 Heidelberg
Search for more papers by this authorE. Hecker
Institute for Biochemistry, German Cancer Research Centre, D-6900 Heidelberg, FRG
Search for more papers by this authorCorresponding Author
S. V. Bhide
Carcinogenesis Division, Cancer Research Institute, Tata Memorial Centre, Parel, Bombay 400 012, India
Carcinogenesis Division, Cancer Research Institute, Tata Memorial Centre, Parel, Bombay 400 012, IndiaSearch for more papers by this authorAbstract
In 50% of BALB/c mice pretreated with atropine, tongue tumours were induced by fortnightly application of DMN-OAc (2 mg/kg) on the tongue. When DMN-OAc + TPA was used for the initiation-promotion protocol, tumours were observed on the tongue, the site of application, in only 10% of animals. In the same group, stomach tumours were obtained in 63% of mice, denoting that initiation-promotion could be successfully used to induce stomach tumours. Using a protocol of DMN-OAc + chilli as a promoter, we observed induction of stomach tumours. The promoter effect of chilli extract was also seen in the BHC-induced hepato-carcinogenesis system. It thus appears that, in BALB/c mice, chilli acts as a promoter in stomach and liver carcinogenesis.
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