Binding of oestradiol to blood proteins and aetiology of breast cancer
Corresponding Author
J. W. Moore
Department of Clinical Endocrinology, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX
Department of Clinical Endocrinology, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PXSearch for more papers by this authorG. M. G. Clark
Department of Clinical Endocrinology, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX
Search for more papers by this authorS. A. Hoare
Department of Clinical Endocrinology, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX
Search for more papers by this authorR. R. Millis
Breast Cancer Unit, Guy's Hospital, London SE1 9RT, UK
Search for more papers by this authorJ. L. Hayward
Breast Cancer Unit, Guy's Hospital, London SE1 9RT, UK
Search for more papers by this authorM. K. Quinlan
Department of Clinical Endocrinology, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX
Search for more papers by this authorD. Y. Wang
Department of Clinical Endocrinology, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX
Search for more papers by this authorR. D. Bulbrook
Department of Clinical Endocrinology, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX
Search for more papers by this authorCorresponding Author
J. W. Moore
Department of Clinical Endocrinology, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX
Department of Clinical Endocrinology, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PXSearch for more papers by this authorG. M. G. Clark
Department of Clinical Endocrinology, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX
Search for more papers by this authorS. A. Hoare
Department of Clinical Endocrinology, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX
Search for more papers by this authorR. R. Millis
Breast Cancer Unit, Guy's Hospital, London SE1 9RT, UK
Search for more papers by this authorJ. L. Hayward
Breast Cancer Unit, Guy's Hospital, London SE1 9RT, UK
Search for more papers by this authorM. K. Quinlan
Department of Clinical Endocrinology, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX
Search for more papers by this authorD. Y. Wang
Department of Clinical Endocrinology, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX
Search for more papers by this authorR. D. Bulbrook
Department of Clinical Endocrinology, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX
Search for more papers by this authorAbstract
A prospective study of 5,000 women has shown that, compared to controls, those who subsequently developed breast cancer had a higher proportion of their blood oestradiol in the non-protein-bound and albumin-bound fractions (the bio-available fraction) and a lower proportion in the sex-hormone-bound fraction. The increased proportion of bio-available oestradiol was partly due to a lower concentration of sex-hormone-binding globulin. Weight was excluded as a confounding factor.
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