Dietary intake of calcium, fiber and other micronutrients in relation to colorectal cancer risk: Results from the Shanghai Women's Health Study
Aesun Shin
Department of Medicine, Center for Health Services Research and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
Search for more papers by this authorHonglan Li
Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
Search for more papers by this authorXiao-Ou Shu
Department of Medicine, Center for Health Services Research and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
Search for more papers by this authorGong Yang
Department of Medicine, Center for Health Services Research and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
Search for more papers by this authorYu-Tang Gao
Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
Search for more papers by this authorCorresponding Author
Wei Zheng
Department of Medicine, Center for Health Services Research and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
Fax: +615-322-1754
Center for Health Services Research, Vanderbilt University Medical Center, Medical Center North, S-1121, 1161 21st Avenue South, Nashville, TN 37232-2587, USASearch for more papers by this authorAesun Shin
Department of Medicine, Center for Health Services Research and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
Search for more papers by this authorHonglan Li
Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
Search for more papers by this authorXiao-Ou Shu
Department of Medicine, Center for Health Services Research and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
Search for more papers by this authorGong Yang
Department of Medicine, Center for Health Services Research and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
Search for more papers by this authorYu-Tang Gao
Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
Search for more papers by this authorCorresponding Author
Wei Zheng
Department of Medicine, Center for Health Services Research and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
Fax: +615-322-1754
Center for Health Services Research, Vanderbilt University Medical Center, Medical Center North, S-1121, 1161 21st Avenue South, Nashville, TN 37232-2587, USASearch for more papers by this authorAbstract
We evaluated the associations of dietary intake of calcium, fiber and vitamins with colorectal cancer risk in a population-based prospective cohort study conducted among Chinese women in Shanghai. Subjects were recruited in urban Shanghai from March 1997 to May 2000. All subjects were interviewed in-person to obtain information on demographic and lifestyle factors and anthropometric measurement was conducted. Usual dietary intake, using a validated food frequency questionnaire was assessed at the baseline survey. After following a total of 73,314 women for a median of 5.74 years, 283 incident colorectal cancer cases were recorded. Excluding the first 2 years of follow-up, a high intake of calcium was associated with a decreased risk of colorectal cancer. Comparing the highest quintile of nutrients intake to the lowest, the adjusted relative risk for colorectal cancer was 0.6 (p value for trend = 0.023) for calcium. No apparent associations were found for fiber, total vitamin A, carotene, vitamins B1, B2, B3, C and E with colorectal cancer risk. Our results suggest that calcium may be protective against colorectal cancer development even at a lower consumption level compared to Western populations. © 2006 Wiley-Liss, Inc.
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