No association between the type 2 diabetes mellitus susceptibility gene, SLC30A8 and schizophrenia in a Chinese population
Corresponding Author
Xuan Zhang
Research Center for Diabetic Complication and Department of Nephrology, the Second Hospital, Jilin University, Changchun, China
Xuan Zhang, Research Center for Diabetic Complication and Department of Nephrology, the Second Hospital, Jilin University, Changchun 130041, China. E-mail: [email protected]
Thomas R Kosten and Xiang Yang Zhang, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. E-mail: [email protected], [email protected]
Search for more papers by this authorSong-Lei Guan
Research Center for Genomic Medicine and MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun, China
Search for more papers by this authorZhen-Qi Wang
Research Center for Genomic Medicine and MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun, China
Search for more papers by this authorYang You
Research Center for Genomic Medicine and MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun, China
Search for more papers by this authorShi-Long Sun
Research Center for Genomic Medicine and MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun, China
Search for more papers by this authorLi Hui
Research Center for Diabetic Complication and Department of Nephrology, the Second Hospital, Jilin University, Changchun, China
Research Center for Genomic Medicine and MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun, China
Search for more papers by this authorLi-ning Miao
Research Center for Diabetic Complication and Department of Nephrology, the Second Hospital, Jilin University, Changchun, China
Search for more papers by this authorYaqin Yu
Research Center for Genomic Medicine and MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun, China
Search for more papers by this authorCorresponding Author
Thomas R Kosten
Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA
Xuan Zhang, Research Center for Diabetic Complication and Department of Nephrology, the Second Hospital, Jilin University, Changchun 130041, China. E-mail: [email protected]
Thomas R Kosten and Xiang Yang Zhang, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. E-mail: [email protected], [email protected]
Search for more papers by this authorCorresponding Author
Xiang Yang Zhang
Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA
Xuan Zhang, Research Center for Diabetic Complication and Department of Nephrology, the Second Hospital, Jilin University, Changchun 130041, China. E-mail: [email protected]
Thomas R Kosten and Xiang Yang Zhang, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. E-mail: [email protected], [email protected]
Search for more papers by this authorCorresponding Author
Xuan Zhang
Research Center for Diabetic Complication and Department of Nephrology, the Second Hospital, Jilin University, Changchun, China
Xuan Zhang, Research Center for Diabetic Complication and Department of Nephrology, the Second Hospital, Jilin University, Changchun 130041, China. E-mail: [email protected]
Thomas R Kosten and Xiang Yang Zhang, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. E-mail: [email protected], [email protected]
Search for more papers by this authorSong-Lei Guan
Research Center for Genomic Medicine and MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun, China
Search for more papers by this authorZhen-Qi Wang
Research Center for Genomic Medicine and MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun, China
Search for more papers by this authorYang You
Research Center for Genomic Medicine and MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun, China
Search for more papers by this authorShi-Long Sun
Research Center for Genomic Medicine and MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun, China
Search for more papers by this authorLi Hui
Research Center for Diabetic Complication and Department of Nephrology, the Second Hospital, Jilin University, Changchun, China
Research Center for Genomic Medicine and MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun, China
Search for more papers by this authorLi-ning Miao
Research Center for Diabetic Complication and Department of Nephrology, the Second Hospital, Jilin University, Changchun, China
Search for more papers by this authorYaqin Yu
Research Center for Genomic Medicine and MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun, China
Search for more papers by this authorCorresponding Author
Thomas R Kosten
Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA
Xuan Zhang, Research Center for Diabetic Complication and Department of Nephrology, the Second Hospital, Jilin University, Changchun 130041, China. E-mail: [email protected]
Thomas R Kosten and Xiang Yang Zhang, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. E-mail: [email protected], [email protected]
Search for more papers by this authorCorresponding Author
Xiang Yang Zhang
Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA
Xuan Zhang, Research Center for Diabetic Complication and Department of Nephrology, the Second Hospital, Jilin University, Changchun 130041, China. E-mail: [email protected]
Thomas R Kosten and Xiang Yang Zhang, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. E-mail: [email protected], [email protected]
Search for more papers by this authorXuan Zhang and Song-Lei Guan contributed equally to this work.
Abstract
Background
The co-occurrence of schizophrenia and type 2 diabetes mellitus (T2DM) has been well documented. Recent genome-wide association studies and meta-analyses have shown robust associations of the solute carrier family 30 member 8 (SLC30A8) gene variants with T2DM in various populations. We examined the involvement of the SLC30A8 in the susceptibility to schizophrenia in a Han Chinese population.
Methods
The SLC30A8 rs13266634 gene polymorphism was genotyped in 837 chronic schizophrenic and 1109 unrelated healthy controls by using a case control design. We also assessed clinical symptoms.
Results
There were no significant differences in the rs13266634 genotype (χ2 = 1.95, df = 2, p = 0.38) and allele (χ2 = 0.47, df = 1, p = 0.50) distributions between the patient and control groups. There was no association between rs13266634 and clinical symptoms.
Conclusion
The SLC30A8 gene variation does not appear to contribute a genetic basis for the co-occurrence of schizophrenia and T2DM. Copyright © 2012 John Wiley & Sons, Ltd.
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