Two New Cytotoxic Alkaloids from Mappianthus iodoides Hand.-Mazz.
Corresponding Author
Xi-Bin Xiao
Department of Hematology, Second Affiliated Hospital, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, P. R. China (phone: +86-571-87783652)
Department of Hematology, Second Affiliated Hospital, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, P. R. China (phone: +86-571-87783652)Search for more papers by this authorYue-Xing Lin
Blood Bank, Second Affiliated Hospital, Zhejiang University, Hangzhou 310009, P. R. China
Search for more papers by this authorGeng-Bo Xu
Department of Hematology, Second Affiliated Hospital, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, P. R. China (phone: +86-571-87783652)
Search for more papers by this authorXu-Bo Gong
Department of Hematology, Second Affiliated Hospital, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, P. R. China (phone: +86-571-87783652)
Search for more papers by this authorYing Gu
Department of Hematology, Second Affiliated Hospital, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, P. R. China (phone: +86-571-87783652)
Search for more papers by this authorJie-Feng Tong
Department of Hematology, Second Affiliated Hospital, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, P. R. China (phone: +86-571-87783652)
Search for more papers by this authorJing Yang
Department of Hematology, Second Affiliated Hospital, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, P. R. China (phone: +86-571-87783652)
Search for more papers by this authorCorresponding Author
Xi-Bin Xiao
Department of Hematology, Second Affiliated Hospital, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, P. R. China (phone: +86-571-87783652)
Department of Hematology, Second Affiliated Hospital, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, P. R. China (phone: +86-571-87783652)Search for more papers by this authorYue-Xing Lin
Blood Bank, Second Affiliated Hospital, Zhejiang University, Hangzhou 310009, P. R. China
Search for more papers by this authorGeng-Bo Xu
Department of Hematology, Second Affiliated Hospital, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, P. R. China (phone: +86-571-87783652)
Search for more papers by this authorXu-Bo Gong
Department of Hematology, Second Affiliated Hospital, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, P. R. China (phone: +86-571-87783652)
Search for more papers by this authorYing Gu
Department of Hematology, Second Affiliated Hospital, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, P. R. China (phone: +86-571-87783652)
Search for more papers by this authorJie-Feng Tong
Department of Hematology, Second Affiliated Hospital, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, P. R. China (phone: +86-571-87783652)
Search for more papers by this authorJing Yang
Department of Hematology, Second Affiliated Hospital, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, P. R. China (phone: +86-571-87783652)
Search for more papers by this authorAbstract
Two new alkaloids, mappine A (1) and mapposidic acid (2), together with eleven known compounds, were isolated from the stems of Mappianthus iodoides Hand.-Mazz. Their structures were elucidated by means of spectroscopic and mass-spectrometric analyses, particularly 1D- and 2D-NMR spectroscopy. The cytotoxic activities of the two new alkaloids were also evaluated.
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