Synthetic Route to Ergot Alkaloids
István Moldvai
Chemical Research Center, Institute of Biomolecular Chemistry, Hungarian Academy of Sciences, POB 17, H-1525 Budapest
Search for more papers by this authorEszter Temesvári-Major
Chemical Research Center, Institute of Biomolecular Chemistry, Hungarian Academy of Sciences, POB 17, H-1525 Budapest
Search for more papers by this authorMária Incze
Chemical Research Center, Institute of Biomolecular Chemistry, Hungarian Academy of Sciences, POB 17, H-1525 Budapest
Search for more papers by this authorGábor Dörnyei
Chemical Research Center, Institute of Biomolecular Chemistry, Hungarian Academy of Sciences, POB 17, H-1525 Budapest
Search for more papers by this authorÉva Szentirmay
Research Group for Alkaloid Chemistry of the Hungarian Academy of Sciences, Budapest University of Technology and Economics, Gellért tér 4, H-1521 Budapest (phone: +36-1-463-1195; fax: +36-1-463-3297)
Search for more papers by this authorCsaba Szántay
Chemical Research Center, Institute of Biomolecular Chemistry, Hungarian Academy of Sciences, POB 17, H-1525 Budapest
Research Group for Alkaloid Chemistry of the Hungarian Academy of Sciences, Budapest University of Technology and Economics, Gellért tér 4, H-1521 Budapest (phone: +36-1-463-1195; fax: +36-1-463-3297)
Search for more papers by this authorIstván Moldvai
Chemical Research Center, Institute of Biomolecular Chemistry, Hungarian Academy of Sciences, POB 17, H-1525 Budapest
Search for more papers by this authorEszter Temesvári-Major
Chemical Research Center, Institute of Biomolecular Chemistry, Hungarian Academy of Sciences, POB 17, H-1525 Budapest
Search for more papers by this authorMária Incze
Chemical Research Center, Institute of Biomolecular Chemistry, Hungarian Academy of Sciences, POB 17, H-1525 Budapest
Search for more papers by this authorGábor Dörnyei
Chemical Research Center, Institute of Biomolecular Chemistry, Hungarian Academy of Sciences, POB 17, H-1525 Budapest
Search for more papers by this authorÉva Szentirmay
Research Group for Alkaloid Chemistry of the Hungarian Academy of Sciences, Budapest University of Technology and Economics, Gellért tér 4, H-1521 Budapest (phone: +36-1-463-1195; fax: +36-1-463-3297)
Search for more papers by this authorCsaba Szántay
Chemical Research Center, Institute of Biomolecular Chemistry, Hungarian Academy of Sciences, POB 17, H-1525 Budapest
Research Group for Alkaloid Chemistry of the Hungarian Academy of Sciences, Budapest University of Technology and Economics, Gellért tér 4, H-1521 Budapest (phone: +36-1-463-1195; fax: +36-1-463-3297)
Search for more papers by this authorAbstract
Rye is sometimes infected by a fungus called Claviceps purpurea. The term ergot designates the dark, brown, tuberous bodies which can be collected before or during harvesting and represent one of the most remarkable drugs of our therapeutic arsenal. Actually, the most significant alkaloids are metabolic products of these fungi. We elaborated three alternative total synthetic pathways to construct the ergoline skeleton, one of which – suitable for scaling up – finally resulted in (+)-lysergic acid (32a) and α-ergocryptine (1) (Schemes 5 and 6).
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