Volume 15, Issue 2 pp. 215-221
Original Article
Free Access

Prognostic features and role of liver transplantation in severe corticosteroid-treated autoimmune chronic active hepatitis

Luis Sanchez-Urdazpal

Luis Sanchez-Urdazpal

the Division of Transplantation Surgery, Mayo Clinic and Mayo Medical School, Rochester, Minnesota 55905

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Albert J. Czaja M.D.

Corresponding Author

Albert J. Czaja M.D.

Hepatobiliary Unit, Division of Gastroenterology, Mayo Clinic and Mayo Medical School, Rochester, Minnesota 55905

Mayo Clinic, Rochester, MN 55905===Search for more papers by this author
Bart van Hoek

Bart van Hoek

Hepatobiliary Unit, Division of Gastroenterology, Mayo Clinic and Mayo Medical School, Rochester, Minnesota 55905

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Ruud A. F. Krom

Ruud A. F. Krom

the Division of Transplantation Surgery, Mayo Clinic and Mayo Medical School, Rochester, Minnesota 55905

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Russell H. Wiesner

Russell H. Wiesner

Hepatobiliary Unit, Division of Gastroenterology, Mayo Clinic and Mayo Medical School, Rochester, Minnesota 55905

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First published: February 1992
Citations: 149

Abstract

To identify prognostic features and to define the role of liver transplantation in severe autoimmune chronic active hepatitis, findings before and after corticosteroid therapy in 111 patients were correlated with outcome and compared with the findings in 24 patients who had been selected independently for liver transplantation. Patients whose condition deteriorated during corticosteroid treatment were younger (32 ± 3 yr vs. 43 ± 2 yr; p < 0.02) than those who experienced remission, but no individual features predicted outcome. Patients in whom therapy failed required longer durations of continuous treatment than did those who experienced remission (60 ± 14 mo vs. 20 ± 12 mo; p = 0.001). Of 13 patients who did not experience remission within 4 yr, 9 (69%) ultimately deteriorated. Ascites developed more often in those patients whose therapy failed and who died of liver failure than in counterparts who survived (86% vs. 33%). Patients undergoing transplantation were similar to those whose treatment failed, but they died less frequently (8% vs. 56%, p < 0.01). Indeed, the 5-yr survival rate after transplantation was comparable to that of patients who had entered remission (92% vs. 100%). Successive biopsy samples failed to disclose recurrent autoimmune hepatitis after transplantation. Human leukocyte antigens Al, B8 occurred more commonly in patients in whom treatment failed or who underwent transplantation (70% vs. 41%, p < 0.05). We conclude that failure to achieve remission within 4 yr and the human leukocyte antigen Al, B8 phenotype are associated with poor prognosis. Manifestations of liver decompensation, such as ascites, in patients who have been unable to experience remission justify consideration of transplantation. Transplantation improves the survival of patients with features of treatment failure, and it is not associated with recurrent disease. (HEPATOLOGY 1991;15:215-221).

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