Volume 11, Issue 4 pp. 570-577
Original Article
Free Access

Estrogen induction of hepatocellular carcinomas in Armenian hamsters

John E. Coe M.D

Corresponding Author

John E. Coe M.D

National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840

National Institutes of Health, NIAID, Lab of Persistent Viral Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840===Search for more papers by this author
Kamal G. Ishak

Kamal G. Ishak

Armed Forces Institute of Pathology, Washington, District of Columbia 20306-6000

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Mary Jane Ross

Mary Jane Ross

National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840

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First published: April 1990
Citations: 32

Abstract

Liver tumors were found in most Armenian hamsters (Cricetulus migratorius) injected with on 15-mg pellet of diethylstilbestrol. The tumors were detectable as early as 1.5 mo after diethylstilbestrol administration and were usually present as multiple nodules that progressively increased in size. Histologically, the multicentric neoplasms were all hepatocellular carcinomas of varied degrees of differentiation and frequently (42.8%) contained Mallory bodies; preneoplastic lesions were not observed. This hepatocellular carcinoma hamster model is unique because estrogen alone without any other known mutagen is responsible for induction of hepatocellular carcinoma.(HEPATOLOGY 1990; 11:570:577.)

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