ORIGINAL ARTICLE
Solid organ transplantation worsens the prognosis of patients with cutaneous squamous cell carcinoma of the head and neck region—Comparison between solid organ transplant recipients and immunocompetent patients
Amit Ritter MD,
Samih Badir MD,
Muhammad Mansour MD,
Zvi Segal MD,
Dean Ad-El MD,
Gideon Bachar MD,
Thomas Shpitzer MD,
Aron Popovtzer MD,
Aviram Mizrachi MD,
Corresponding Author
Amit Ritter MD
Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Correspondence
Amit Ritter, Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva 49100, Israel.
Email: [email protected]
Search for more papers by this authorSamih Badir MD
Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Search for more papers by this authorMuhammad Mansour MD
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Department of Plastic Surgery and Burns, Rabin Medical Center, Petah Tikva, Israel
Search for more papers by this authorZvi Segal MD
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Department of Plastic Surgery and Burns, Rabin Medical Center, Petah Tikva, Israel
Search for more papers by this authorDean Ad-El MD
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Department of Plastic Surgery and Burns, Rabin Medical Center, Petah Tikva, Israel
Search for more papers by this authorGideon Bachar MD
Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Search for more papers by this authorThomas Shpitzer MD
Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Search for more papers by this authorAron Popovtzer MD
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Davidoff Cancer Center, Rabin Medical Center, Petah Tikva, Israel
Search for more papers by this authorAviram Mizrachi MD
Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Search for more papers by this authorAmit Ritter MD,
Samih Badir MD,
Muhammad Mansour MD,
Zvi Segal MD,
Dean Ad-El MD,
Gideon Bachar MD,
Thomas Shpitzer MD,
Aron Popovtzer MD,
Aviram Mizrachi MD,
Corresponding Author
Amit Ritter MD
Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Correspondence
Amit Ritter, Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva 49100, Israel.
Email: [email protected]
Search for more papers by this authorSamih Badir MD
Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Search for more papers by this authorMuhammad Mansour MD
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Department of Plastic Surgery and Burns, Rabin Medical Center, Petah Tikva, Israel
Search for more papers by this authorZvi Segal MD
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Department of Plastic Surgery and Burns, Rabin Medical Center, Petah Tikva, Israel
Search for more papers by this authorDean Ad-El MD
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Department of Plastic Surgery and Burns, Rabin Medical Center, Petah Tikva, Israel
Search for more papers by this authorGideon Bachar MD
Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Search for more papers by this authorThomas Shpitzer MD
Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Search for more papers by this authorAron Popovtzer MD
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Davidoff Cancer Center, Rabin Medical Center, Petah Tikva, Israel
Search for more papers by this authorAviram Mizrachi MD
Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Search for more papers by this authorAbstract
Background
Cutaneous squamous cell carcinoma of the head and neck (CSCC-HN) appears to behave more aggressively in immunosuppressed patients. We aimed to investigate this hypothesis by comparing solid organ transplant recipients (SOTR) with CSCC-HN to immunocompetent patients.
Methods
A retrospective comparative study was conducted for SOTR and immunocompetent patients who were treated for CSCC-HN.
Results
A total of 177 SOTR and 157 immunocompetent patients with CSCC-HN were included. Lymph node metastases were more common in the SOTR group (9% vs 3%), and distant metastases occurred only in SOTR (3% of patients). SOTR had a higher rate of recurrences (19% vs 10%), which were mostly regional (7%) and distant (3%). The 2-year disease-specific survival of SOTR was lower (93% vs 100%).
Conclusions
SOTR with CSCC-HN has significantly worse outcomes compared to immunocompetent patients. Solid-organ transplantation should be regarded as a negative prognostic factor in patients with CSCC-HN.
CONFLICT OF INTEREST
The authors have no conflicts of interest to disclose.
Open Research
DATA AVAILABILITY STATEMENT
Author elects to not share data
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