18F-FDG PET/MRI vs MRI in patients with recurrent adenoid cystic carcinoma
Julian Kirchner MD
Department of Diagnostic and Interventional Radiology, University of Dusseldorf, Medical Faculty, Dusseldorf, Germany
Search for more papers by this authorCorresponding Author
Benedikt M. Schaarschmidt MD
Department of Diagnostic and Interventional Radiology, University of Dusseldorf, Medical Faculty, Dusseldorf, Germany
Correspondence
Benedikt M. Schaarschmidt, University of Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Moorenstrasse 5, D-40225 Dusseldorf, Germany.
Email: [email protected]
Search for more papers by this authorWolfgang Sauerwein MD
Department of Radiation Oncology, University of Duisburg-Essen, Essen, Germany
Search for more papers by this authorCornelius Deuschl MD
Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Search for more papers by this authorDiana Arweiler-Harbeck MD
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Search for more papers by this authorLaura Holtmann MD
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Search for more papers by this authorVanessa Stebner MD
Department of Nuclear Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Search for more papers by this authorLale Umutlu MD
Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Search for more papers by this authorGerald Antoch MD
Department of Diagnostic and Interventional Radiology, University of Dusseldorf, Medical Faculty, Dusseldorf, Germany
Search for more papers by this authorVerena Ruhlmann MD
Department of Nuclear Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Search for more papers by this authorJulian Kirchner MD
Department of Diagnostic and Interventional Radiology, University of Dusseldorf, Medical Faculty, Dusseldorf, Germany
Search for more papers by this authorCorresponding Author
Benedikt M. Schaarschmidt MD
Department of Diagnostic and Interventional Radiology, University of Dusseldorf, Medical Faculty, Dusseldorf, Germany
Correspondence
Benedikt M. Schaarschmidt, University of Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Moorenstrasse 5, D-40225 Dusseldorf, Germany.
Email: [email protected]
Search for more papers by this authorWolfgang Sauerwein MD
Department of Radiation Oncology, University of Duisburg-Essen, Essen, Germany
Search for more papers by this authorCornelius Deuschl MD
Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Search for more papers by this authorDiana Arweiler-Harbeck MD
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Search for more papers by this authorLaura Holtmann MD
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Search for more papers by this authorVanessa Stebner MD
Department of Nuclear Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Search for more papers by this authorLale Umutlu MD
Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Search for more papers by this authorGerald Antoch MD
Department of Diagnostic and Interventional Radiology, University of Dusseldorf, Medical Faculty, Dusseldorf, Germany
Search for more papers by this authorVerena Ruhlmann MD
Department of Nuclear Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Search for more papers by this authorAbstract
Objectives
To evaluate and compare the diagnostic potential of 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18FDG-PET/MRI) and MRI for recurrence diagnostics after primary therapy in patients with adenoid cystic carcinoma (ACC).
Methods
A total of 32 dedicated head and neck 18F-FDG PET/MRI datasets were included in this analysis. MRI and 18F-FDG PET/MRI datasets were analyzed in separate sessions by two readers for tumor recurrence or metastases.
Results
Lesion-based sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy were 96%, 84%, 90%, 93%, and 91% for 18F-FDG PET/MRI and 77%, 94%, 95%, 73%, and 84% for MRI, resulting in a significantly higher diagnostic accuracy of 18F-FDG PET/MRI compared to MRI (P < .005).
Conclusion
18F-FDG PET/MRI is superior to MRI in detecting local recurrence and metastases in patients with ACC of the head and neck. Especially concerning its negative predictive value, 18F-FDG PET/MRI outperforms MRI.
CONFLICT OF INTEREST
Benedikt M. Schaarschmidt is a stockholder for General Electric and was a stockholder for Bayer AG, Siemens AG, Siemens Healthineers AG, TEVA Pharmaceuticals till September 2018. All other authors declare that they have no conflict of interest.
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