ORIGINAL ARTICLE

Compartmental surgery for oral tongue and floor of the mouth cancer: Oncologic outcomes

Corresponding Author

Cesare Piazza MD

orcid.org/0000-0002-2391-9357

Department of Otorhinolaryngology, Head and Neck Surgery, Fondazione IRCCS, National Cancer Institute of Milan, University of Milan, Milan, Italy

Correspondence

Cesare Piazza, MD, Department of Otorhinolaryngology, Head and Neck Surgery, Fondazione IRCCS, National Cancer Institute of Milan, University of Milan, Via Giacomo Venezian 1, 20133 Milan, Italy.

Email: [email protected]; [email protected]

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Alberto Grammatica MD,

Alberto Grammatica MD

Department of Otorhinolaryngology, Head and Neck Surgery, University of Brescia, Milan, Italy

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Nausica Montalto MD,

Nausica Montalto MD

Department of Otorhinolaryngology, Head and Neck Surgery, University of Brescia, Milan, Italy

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Alberto Paderno MD,

Alberto Paderno MD

Department of Otorhinolaryngology, Head and Neck Surgery, University of Brescia, Milan, Italy

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Francesca Del Bon MD,

Francesca Del Bon MD

Department of Otorhinolaryngology, Head and Neck Surgery, University of Brescia, Milan, Italy

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Piero Nicolai MD,

Piero Nicolai MD

Department of Otorhinolaryngology, Head and Neck Surgery, University of Brescia, Milan, Italy

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Cesare Piazza MD,

Corresponding Author

Cesare Piazza MD

orcid.org/0000-0002-2391-9357

Department of Otorhinolaryngology, Head and Neck Surgery, Fondazione IRCCS, National Cancer Institute of Milan, University of Milan, Milan, Italy

Correspondence

Cesare Piazza, MD, Department of Otorhinolaryngology, Head and Neck Surgery, Fondazione IRCCS, National Cancer Institute of Milan, University of Milan, Via Giacomo Venezian 1, 20133 Milan, Italy.

Email: [email protected]; [email protected]

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Alberto Grammatica MD,

Alberto Grammatica MD

Department of Otorhinolaryngology, Head and Neck Surgery, University of Brescia, Milan, Italy

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Nausica Montalto MD,

Nausica Montalto MD

Department of Otorhinolaryngology, Head and Neck Surgery, University of Brescia, Milan, Italy

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Alberto Paderno MD,

Alberto Paderno MD

Department of Otorhinolaryngology, Head and Neck Surgery, University of Brescia, Milan, Italy

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Francesca Del Bon MD,

Francesca Del Bon MD

Department of Otorhinolaryngology, Head and Neck Surgery, University of Brescia, Milan, Italy

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Piero Nicolai MD,

Piero Nicolai MD

Department of Otorhinolaryngology, Head and Neck Surgery, University of Brescia, Milan, Italy

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First published: 11 December 2018

https://doi.org/10.1002/hed.25480

Citations: 43

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Abstract

Background

Oral tongue/floor of mouth squamous cell carcinoma (OTFMSCC) with a depth of invasion (DOI) > 10 mm involves extrinsic muscles and lingual neurovascular/lymphatic bundles. “Compartmental” hemiglossopelvectomy (CHGP) was developed to improve loco-regional control by “en bloc” removal of tumor and its pathways of spread.

Methods

We conducted a retrospective observational study on 45 CHGPs performed at a single institution for OTFMSCC with a DOI > 10 mm at CT/MR. Group A (n = 35) included naïve patients, and group B (n = 10) recurrent cancers. We evaluated 2-year overall survival (OS), disease-free survival (DFS), local control (LC), and loco-regional control (LRC).

Results

Two-year OS, DFS, LC, and LRC were 80%, 91%, 100%, and 94% for group A, and 27%, 26%, 67%, and 36% for group B, respectively. Salvage surgery and positive margins were significantly associated with worse prognosis.

Conclusion

CHGP is a reliable oncologic approach in primary surgery for advanced OTFMSCC. In recurrent cancers, survival remains poor.

CONFLICT OF INTERESTS

None declared.

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Volume41, Issue1

January 2019

Pages 110-115

Compartmental surgery for oral tongue and floor of the mouth cancer: Oncologic outcomes

Abstract

Background

Methods

Results

Conclusion

CONFLICT OF INTERESTS

REFERENCES

Citing Literature

References

Information

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Compartmental surgery for oral tongue and floor of the mouth cancer: Oncologic outcomes

Abstract

Background

Methods

Results

Conclusion

CONFLICT OF INTERESTS

REFERENCES

Citing Literature

References

Related

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