Volume 39, Issue 1 pp. 133-139

Original Article

Role of surgery in the management of anaplastic thyroid carcinoma: Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012

Seung-Kuk Baek MD, PhD,

Seung-Kuk Baek MD, PhD

Department of Otorhinolaryngology–Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea

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Myung-Chul Lee MD, PhD,

Myung-Chul Lee MD, PhD

Department of Otolaryngology – Head and Neck Surgery, Korea Cancer Center Hospital, Seoul, Korea

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J. Hun Hah MD, PhD,

J. Hun Hah MD, PhD

Department of Otorhinolaryngology – Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea

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Soon-Hyun Ahn MD, PhD,

Soon-Hyun Ahn MD, PhD

Department of Otorhinolaryngology – Head and Neck Surgery, Seoul National University Bundang Hospital, Seoul, Korea

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Young-Ik Son MD, PhD,

Young-Ik Son MD, PhD

Department of Otorhinolaryngology – Head and Neck Surgery, Sungkyunkwan University School of Medicine, Gyeonggi-do, Korea

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Young-Soo Rho MD, PhD,

Young-Soo Rho MD, PhD

Department of Otorhinolaryngology – Head and Neck Surgery, Hallym University College of Medicine, Gangwon-do, Korea

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Phil-Sang Chung MD, PhD,

Phil-Sang Chung MD, PhD

Department of Otorhinolaryngology – Head and Neck Surgery, Dankook University College of Medicine, Chungnam, Korea

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Yoon-Se Lee MD, PhD,

Yoon-Se Lee MD, PhD

Department of Otorhinolaryngology – Head and Neck Surgery, Ulsan University College of Medicine, Seoul, Korea

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Bon Seok Koo MD, PhD,

Bon Seok Koo MD, PhD

Department of Otorhinolaryngology–Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, 305-764 Korea

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Kwang-Yoon Jung MD, PhD,

Kwang-Yoon Jung MD, PhD

Department of Otorhinolaryngology–Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea

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Byung-Joo Lee MD, PhD,

Corresponding Author

Byung-Joo Lee MD, PhD

[email protected]

Department of Otorhinolaryngology – Head and Neck Surgery, Pusan National University School of Medicine and Biomedical Research Institute, Busan, Korea

Corresponding author: B.-J. Lee, Department of Otorhinolaryngology – Head and Neck Surgery, Pusan National University School of Medicine and Biomedical Research Institute, 1-10 Ami-Dong, Seo-Gu, Busan 602-739, Korea. E-mail: [email protected]Search for more papers by this author

Seung-Kuk Baek MD, PhD,

Seung-Kuk Baek MD, PhD

Department of Otorhinolaryngology–Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea

Search for more papers by this author

Myung-Chul Lee MD, PhD,

Myung-Chul Lee MD, PhD

Department of Otolaryngology – Head and Neck Surgery, Korea Cancer Center Hospital, Seoul, Korea

Search for more papers by this author

J. Hun Hah MD, PhD,

J. Hun Hah MD, PhD

Department of Otorhinolaryngology – Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea

Search for more papers by this author

Soon-Hyun Ahn MD, PhD,

Soon-Hyun Ahn MD, PhD

Department of Otorhinolaryngology – Head and Neck Surgery, Seoul National University Bundang Hospital, Seoul, Korea

Search for more papers by this author

Young-Ik Son MD, PhD,

Young-Ik Son MD, PhD

Department of Otorhinolaryngology – Head and Neck Surgery, Sungkyunkwan University School of Medicine, Gyeonggi-do, Korea

Search for more papers by this author

Young-Soo Rho MD, PhD,

Young-Soo Rho MD, PhD

Department of Otorhinolaryngology – Head and Neck Surgery, Hallym University College of Medicine, Gangwon-do, Korea

Search for more papers by this author

Phil-Sang Chung MD, PhD,

Phil-Sang Chung MD, PhD

Department of Otorhinolaryngology – Head and Neck Surgery, Dankook University College of Medicine, Chungnam, Korea

Search for more papers by this author

Yoon-Se Lee MD, PhD,

Yoon-Se Lee MD, PhD

Department of Otorhinolaryngology – Head and Neck Surgery, Ulsan University College of Medicine, Seoul, Korea

Search for more papers by this author

Bon Seok Koo MD, PhD,

Bon Seok Koo MD, PhD

Department of Otorhinolaryngology–Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, 305-764 Korea

Search for more papers by this author

Kwang-Yoon Jung MD, PhD,

Kwang-Yoon Jung MD, PhD

Department of Otorhinolaryngology–Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea

Search for more papers by this author

Byung-Joo Lee MD, PhD,

Corresponding Author

Byung-Joo Lee MD, PhD

[email protected]

Department of Otorhinolaryngology – Head and Neck Surgery, Pusan National University School of Medicine and Biomedical Research Institute, Busan, Korea

First published: 18 August 2016

https://doi.org/10.1002/hed.24559

Citations: 35

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ABSTRACT

Background

The Korean Society of Thyroid Head and Neck Surgery established a nationwide multicenter registry of anaplastic thyroid carcinoma (ATC) and evaluated the prognostic factors and treatment outcomes of ATC.

Methods

The present study enrolled 329 patients who were diagnosed with ATC between January 2000 and December 2012 at 19 medical centers in Korea. Survival outcomes were evaluated according to various clinical factors and treatments.

Results

Multivariate analysis identified age ≥70 years old, the presence of initial clinical symptoms, distant metastasis, and treatment modality as significant risk factors (p <.05). The patients who underwent curative resection and adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CRT) showed the best survival on multivariate analysis (p < 0.05).

Conclusion

Although ATC is a lethal neoplasm, long-term survival may be acquired in cases in which the aggressive management, including curative resection or RT/concurrent CRT, is possible for therapeutic intent. © 2016 Wiley Periodicals, Inc. Head Neck 39: 133–139, 2017

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Volume39, Issue1

January 2017

Pages 133-139

Role of surgery in the management of anaplastic thyroid carcinoma: Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012

ABSTRACT

Background

Methods

Results

Conclusion

REFERENCES

Citing Literature

References

Information

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Role of surgery in the management of anaplastic thyroid carcinoma: Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012

ABSTRACT

Background

Methods

Results

Conclusion

REFERENCES

Citing Literature

References

Related

Information