Original Article

Diagnostic role of core needle biopsy in cervical lymphadenopathy

Yoon-Jong Ryu MD

Department of Otorhinolaryngology Head and Neck Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, South Korea

Search for more papers by this author

Wonjae Cha MD,

Wonjae Cha MD

Department of Otorhinolaryngology Head and Neck Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, South Korea

Search for more papers by this author

Woo-Jin Jeong MD,

Woo-Jin Jeong MD

Department of Otorhinolaryngology Head and Neck Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, South Korea

Search for more papers by this author

Sang Il Choi MD,

Sang Il Choi MD

Department of Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, South Korea

Search for more papers by this author

Soon-Hyun Ahn MD,

Corresponding Author

Soon-Hyun Ahn MD

Department of Otorhinolaryngology Head and Neck Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, South Korea

Corresponding author: S.-H. Ahn, Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Goomi-Dong, Bundang-Gu, Seongnam-Si, Kyunggi-Do, 463-707, Seoul, South Korea. E-mail: [email protected]Search for more papers by this author

Yoon-Jong Ryu MD,

Yoon-Jong Ryu MD

Department of Otorhinolaryngology Head and Neck Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, South Korea

Search for more papers by this author

Wonjae Cha MD,

Wonjae Cha MD

Department of Otorhinolaryngology Head and Neck Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, South Korea

Search for more papers by this author

Woo-Jin Jeong MD,

Woo-Jin Jeong MD

Department of Otorhinolaryngology Head and Neck Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, South Korea

Search for more papers by this author

Sang Il Choi MD,

Sang Il Choi MD

Department of Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, South Korea

Search for more papers by this author

Soon-Hyun Ahn MD,

Corresponding Author

Soon-Hyun Ahn MD

Department of Otorhinolaryngology Head and Neck Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, South Korea

First published: 22 December 2013

https://doi.org/10.1002/hed.23580

Citations: 30

Share a link

Email
Wechat
Bluesky

ABSTRACT

Background

The purpose of this study was to evaluate the value of core needle biopsy (CNB) compared to fine-needle aspiration cytology (FNAC) in cervical lymphadenopathy.

Methods

This consecutive case series enrolled 208 patients with cervical lymphadenopathy. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were evaluated and the necessity of an additional open biopsy was compared.

Results

The sensitivity and NPV for critical disease (lymphoma, carcinoma, and tuberculosis) were significantly higher with CNB (p = .006, p = .001, respectively) than with FNAC. In the analysis based on specific disease, the sensitivity of CNB was statistically significantly higher (p = .009) for the diagnosis of lymphoma. The rate of open biopsy for confirmative diagnosis was significantly lower with CNB (p = .014).

Conclusion

CNB is beneficial for initial examination in cervical lymphadenopathy and showed higher sensitivity and NPV than FNAC. It is especially useful for screening for lymphoma. © 2014 Wiley Periodicals, Inc. Head Neck 37: 229-233, 2015

REFERENCES

1 Steel BL, Schwartz MR, Ramzy I. Fine needle aspiration biopsy in the diagnosis of lymphadenopathy in 1,103 patients. Role, limitations and analysis of diagnostic pitfalls. Acta Cytol 1995; 39: 76–81.
CAS PubMed Web of Science® Google Scholar
2 Nasuti JF, Yu G, Boudousquie A, Gupta P. Diagnostic value of lymph node fine needle aspiration cytology: an institutional experience of 387 cases observed over a 5-year period. Cytopathology 2000; 11: 18–31.
10.1046/j.1365-2303.2000.00208.x
CAS PubMed Web of Science® Google Scholar
3 Baek CH, Kim SI, Ko YH, Chu KC. Polymerase chain reaction detection of mycobacterium tuberculosis from fine-needle aspirate for the diagnosis of cervical tuberculous lymphadenitis. Laryngoscope 2000; 110: 30–34.
10.1097/00005537-200001000-00006
CAS PubMed Web of Science® Google Scholar
4 Demharter J, Müller P, Wagner T, Schlimok G, Haude K, Bohndorf K. Percutaneous core-needle biopsy of enlarged lymph nodes in the diagnosis and subclassification of malignant lymphomas. Eur Radiol 2001; 11: 276–283.
10.1007/s003300000540
CAS PubMed Web of Science® Google Scholar
5 Screaton NJ, Berman LH, Grant JW. Head and neck lymphadenopathy: evaluation with US-guided cutting-needle biopsy. Radiology 2002; 224: 75–81.
10.1148/radiol.2241010602
PubMed Web of Science® Google Scholar
6 Douville NJ, Bradford CR. Comparison of ultrasound-guided core biopsy versus fine-needle aspiration biopsy in the evaluation of salivary gland lesions. Head Neck 2013; 35: 1657–1661.
10.1002/hed.23193
PubMed Web of Science® Google Scholar
7 Nagar S, Iacco A, Riggs T, Kestenberg W, Keidan R. An analysis of fine needle aspiration versus core needle biopsy in clinically palpable breast lesions: a report on the predictive values and a cost comparison. Am J Surg 2012; 204: 193–198.
10.1016/j.amjsurg.2011.10.018
PubMed Web of Science® Google Scholar
8 Park KT, Ahn SH, Mo JH, et al. Role of core needle biopsy and ultrasonographic finding in management of indeterminate thyroid nodules. Head Neck 2011; 33: 160–165.
10.1002/hed.21414
PubMed Web of Science® Google Scholar
9 Schafernak KT, Kluskens LF, Ariga R, Reddy VB, Gattuso P. Fine-needle aspiration of superficial and deeply seated lymph nodes on patients with and without a history of malignancy: review of 439 cases. Diagn Cytopathol 2003; 29: 315–319.
10.1002/dc.10346
PubMed Web of Science® Google Scholar
10 Roussel F, Nouvet G. Evaluation of large-needle biopsy for the diagnosis of cancer. Acta Cytol 1995; 39: 449–452.
CAS PubMed Web of Science® Google Scholar
11 Annam V, Kulkarni MH, Puranik RB. Clinicopathologic profile of significant cervical lymphadenopathy in children aged 1–12 years. Acta Cytol 2009; 53: 174–178.
10.1159/000325120
PubMed Web of Science® Google Scholar
12 Jeong WJ, Park MW, Park SJ, Ahn SH. Initial work-up for cervical lymphadenopathy: back to basics. Eur Arch Otorhinolaryngol 2012; 269: 2255–2263.
10.1007/s00405-011-1895-1
PubMed Web of Science® Google Scholar
13 Tong TR, Chan OW, Lee KC. Diagnosing Kikuchi disease on fine needle aspiration biopsy: a retrospective study of 44 cases diagnosed by cytology and 8 by histopathology. Acta Cytol 2001; 45: 953–957.
10.1159/000328370
CAS PubMed Web of Science® Google Scholar

Citing Literature

Volume37, Issue2

February 2015

Pages 229-233

Diagnostic role of core needle biopsy in cervical lymphadenopathy

ABSTRACT

Background

Methods

Results

Conclusion

REFERENCES

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Diagnostic role of core needle biopsy in cervical lymphadenopathy

ABSTRACT

Background

Methods

Results

Conclusion

REFERENCES

Citing Literature

References

Related

Information