Oncologic results of the surgical salvage of recurrent laryngeal squamous cell carcinoma in a multicentric retrospective series: Emerging role of supracricoid partial laryngectomy
Marco de Vincentiis MD
Department of Sensorial Organs, Ear, Nose, and Throat Section, “Sapienza” University of Rome, Italy
Search for more papers by this authorArmando De Virgilio MD
Department of Sensorial Organs, Ear, Nose, and Throat Section, “Sapienza” University of Rome, Italy
Search for more papers by this authorCorresponding Author
Francesco Bussu MD, PhD
Institute of Otolaryngology, Catholic University of Sacred Heart, Rome, Italy
Corresponding author: F. Bussu, Institute of Otorhinolaryngology, Universitá Cattolica, Policlinico Agostino Gemelli, 00168 Rome, Italy. E-mail: [email protected].Search for more papers by this authorRoberto Gallus MD
Institute of Otolaryngology, Catholic University of Sacred Heart, Rome, Italy
Search for more papers by this authorAndrea Gallo MD
Department of Surgical Biotechnologies and Science, Ear, Nose, and Throat Section, “Sapienza” University of Rome, Italy
Search for more papers by this authorGiovanni Bastanza MD
Institute of Otolaryngology, Catholic University of Sacred Heart, Rome, Italy
Search for more papers by this authorClaudio Parrilla MD
Institute of Otolaryngology, Catholic University of Sacred Heart, Rome, Italy
Search for more papers by this authorAntonio Greco MD
Department of Sensorial Organs, Ear, Nose, and Throat Section, “Sapienza” University of Rome, Italy
Search for more papers by this authorJacopo Galli MD
Institute of Otolaryngology, Catholic University of Sacred Heart, Rome, Italy
Search for more papers by this authorRosaria Turchetta MD
Department of Sensorial Organs, Ear, Nose, and Throat Section, “Sapienza” University of Rome, Italy
Search for more papers by this authorGiovanni Almadori MD
Institute of Otolaryngology, Catholic University of Sacred Heart, Rome, Italy
Search for more papers by this authorGiulio Pagliuca MD
Department of Surgical Biotechnologies and Science, Ear, Nose, and Throat Section, “Sapienza” University of Rome, Italy
Search for more papers by this authorVincenzo Valentini MD
Institute of Radiation Oncology, Catholic University of Sacred Heart, Rome, Italy
Search for more papers by this authorGaetano Paludetti MD
Institute of Otolaryngology, Catholic University of Sacred Heart, Rome, Italy
Search for more papers by this authorMarco de Vincentiis MD
Department of Sensorial Organs, Ear, Nose, and Throat Section, “Sapienza” University of Rome, Italy
Search for more papers by this authorArmando De Virgilio MD
Department of Sensorial Organs, Ear, Nose, and Throat Section, “Sapienza” University of Rome, Italy
Search for more papers by this authorCorresponding Author
Francesco Bussu MD, PhD
Institute of Otolaryngology, Catholic University of Sacred Heart, Rome, Italy
Corresponding author: F. Bussu, Institute of Otorhinolaryngology, Universitá Cattolica, Policlinico Agostino Gemelli, 00168 Rome, Italy. E-mail: [email protected].Search for more papers by this authorRoberto Gallus MD
Institute of Otolaryngology, Catholic University of Sacred Heart, Rome, Italy
Search for more papers by this authorAndrea Gallo MD
Department of Surgical Biotechnologies and Science, Ear, Nose, and Throat Section, “Sapienza” University of Rome, Italy
Search for more papers by this authorGiovanni Bastanza MD
Institute of Otolaryngology, Catholic University of Sacred Heart, Rome, Italy
Search for more papers by this authorClaudio Parrilla MD
Institute of Otolaryngology, Catholic University of Sacred Heart, Rome, Italy
Search for more papers by this authorAntonio Greco MD
Department of Sensorial Organs, Ear, Nose, and Throat Section, “Sapienza” University of Rome, Italy
Search for more papers by this authorJacopo Galli MD
Institute of Otolaryngology, Catholic University of Sacred Heart, Rome, Italy
Search for more papers by this authorRosaria Turchetta MD
Department of Sensorial Organs, Ear, Nose, and Throat Section, “Sapienza” University of Rome, Italy
Search for more papers by this authorGiovanni Almadori MD
Institute of Otolaryngology, Catholic University of Sacred Heart, Rome, Italy
Search for more papers by this authorGiulio Pagliuca MD
Department of Surgical Biotechnologies and Science, Ear, Nose, and Throat Section, “Sapienza” University of Rome, Italy
Search for more papers by this authorVincenzo Valentini MD
Institute of Radiation Oncology, Catholic University of Sacred Heart, Rome, Italy
Search for more papers by this authorGaetano Paludetti MD
Institute of Otolaryngology, Catholic University of Sacred Heart, Rome, Italy
Search for more papers by this authorAbstract
Background
Several studies in the last decade evaluated conservative surgical procedures and, in particular, supracricoid operations as an alternative to total laryngectomy for the salvage of recurrences of laryngeal squamous cell carcinoma (SCC) after a first attempt of organ preservation.
Methods
The clinical records of 68 consecutive patients primarily treated by irradiation or endoscopic surgery and surgically salvaged by total laryngectomy or supracricoid partial laryngectomy in 2 large university hospitals in Italy from 2004 to 2010 were reviewed.
Results
The survival was not affected by the primary treatment or by salvage modality. The only parameter always keeping a prognostic value is the involvement of resection margins of salvage surgery. Patients with early relapse seem to have a worse prognosis than patients with a delayed relapse (p = .05 at Cox multivariate analysis and p = .048 at Wilcoxon test for overall survival [OS] from the primary treatment).
Conclusion
Supracricoid operations, if the indications are careful, can prove reliable salvage procedures. © 2014 Wiley Periodicals, Inc. Head Neck 37: 84–91, 2015
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