Neuroendocrine tumors of the thyroid encompass a wide differential diagnosis. The most common is medullary thyroid carcinoma. One must consider other possibilities when a neuroendocrine thyroid tumor is calcitonin negative. We report 2 cases of Ewing sarcoma of the thyroid and discuss the differential diagnosis and workup of a calcitonin-negative neuroendocrine tumor of the thyroid.

Methods/Results

This is a retrospective review of 2 patients diagnosed with Ewing sarcoma of the thyroid and a review of the literature.

Conclusions

Ewing sarcoma of the thyroid is an exceedingly rare diagnosis, but should be included in the differential diagnosis for a thyroidal neuroendocrine lesion (especially in the absence of calcitonin). The use and interpretation of immunohistochemistry (IHC) and fluorescent in situ hybridization are essential in making the correct diagnosis. © 2013 Wiley Periodicals, Inc. Head Neck, 35: E346–E350, 2013

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Volume35, Issue11

November 2013

Pages E346-E350

Ewing sarcoma of the thyroid: Report of 2 cases and review of the literature

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Background

Methods/Results

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Ewing sarcoma of the thyroid: Report of 2 cases and review of the literature

Abstract

Background

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Conclusions

REFERENCES

Citing Literature

References

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