Volume 33, Issue 10 pp. 1486-1492
Original Article

Retained role of surgery for olfactory neuroblastoma

Robert I. Smee FRANZCR

Corresponding Author

Robert I. Smee FRANZCR

Department of Radiation Oncology, The Prince of Wales Cancer Centre, Randwick, New South Wales, Australia

Department of Radiation Oncology, The Prince of Wales Cancer Centre, Randwick, New South Wales, AustraliaSearch for more papers by this author
Kathryn Broadley

Kathryn Broadley

Department of Radiation Oncology, The Prince of Wales Cancer Centre, Randwick, New South Wales, Australia

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Janet R. Williams SRN

Janet R. Williams SRN

Department of Radiation Oncology, The Prince of Wales Cancer Centre, Randwick, New South Wales, Australia

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Nicola S. Meagher MPH

Nicola S. Meagher MPH

Integrated Cancer Research, UNSW Cancer Research Centre Faculty of Medicine, University of New South Wales, Randwick, New South Wales, Australia

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G. Patrick Bridger FRACS, MD

G. Patrick Bridger FRACS, MD

Department of Otolaryngology, The Prince of Wales Cancer Centre, Randwick, New South Wales, Australia

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First published: 15 December 2010
Citations: 17

Abstract

Background

Olfactory neuroblastoma is a rare paranasal sinus malignancy. The traditional approach was craniofacial resection (CFR) and then postoperative radiotherapy until 1998. This review will chart development of a new protocol.

Methods

This ethics-approved audit evaluated the number of new patients diagnosed with olfactory neuroblastoma, with information relating to patient, disease, and treatment factors noted.

Results

There were 24 eligible patients, 16 men, 8 women, 7 Kadish stage B, 17 stage C. The planned treatment was: chemotherapy (cisplatin/etoposide) and determine treatment dependent on response in 6 patients, surgery and radiotherapy in 16 patients, and single-modality treatment only (surgery, radiotherapy 1) in 2 patients. Surgery to radiotherapy occurred in 17 patients. With salvage treatment ultimate local control was 79%.

Conclusions

There was a higher local control in those patients who had surgery; abandoning this may carry a higher risk of local failure. The use of response to chemotherapy to determine local treatment remains experimental. © 2010 Wiley Periodicals, Inc. Head Neck, 2010

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