Retained role of surgery for olfactory neuroblastoma
Corresponding Author
Robert I. Smee FRANZCR
Department of Radiation Oncology, The Prince of Wales Cancer Centre, Randwick, New South Wales, Australia
Department of Radiation Oncology, The Prince of Wales Cancer Centre, Randwick, New South Wales, AustraliaSearch for more papers by this authorKathryn Broadley
Department of Radiation Oncology, The Prince of Wales Cancer Centre, Randwick, New South Wales, Australia
Search for more papers by this authorJanet R. Williams SRN
Department of Radiation Oncology, The Prince of Wales Cancer Centre, Randwick, New South Wales, Australia
Search for more papers by this authorNicola S. Meagher MPH
Integrated Cancer Research, UNSW Cancer Research Centre Faculty of Medicine, University of New South Wales, Randwick, New South Wales, Australia
Search for more papers by this authorG. Patrick Bridger FRACS, MD
Department of Otolaryngology, The Prince of Wales Cancer Centre, Randwick, New South Wales, Australia
Search for more papers by this authorCorresponding Author
Robert I. Smee FRANZCR
Department of Radiation Oncology, The Prince of Wales Cancer Centre, Randwick, New South Wales, Australia
Department of Radiation Oncology, The Prince of Wales Cancer Centre, Randwick, New South Wales, AustraliaSearch for more papers by this authorKathryn Broadley
Department of Radiation Oncology, The Prince of Wales Cancer Centre, Randwick, New South Wales, Australia
Search for more papers by this authorJanet R. Williams SRN
Department of Radiation Oncology, The Prince of Wales Cancer Centre, Randwick, New South Wales, Australia
Search for more papers by this authorNicola S. Meagher MPH
Integrated Cancer Research, UNSW Cancer Research Centre Faculty of Medicine, University of New South Wales, Randwick, New South Wales, Australia
Search for more papers by this authorG. Patrick Bridger FRACS, MD
Department of Otolaryngology, The Prince of Wales Cancer Centre, Randwick, New South Wales, Australia
Search for more papers by this authorAbstract
Background
Olfactory neuroblastoma is a rare paranasal sinus malignancy. The traditional approach was craniofacial resection (CFR) and then postoperative radiotherapy until 1998. This review will chart development of a new protocol.
Methods
This ethics-approved audit evaluated the number of new patients diagnosed with olfactory neuroblastoma, with information relating to patient, disease, and treatment factors noted.
Results
There were 24 eligible patients, 16 men, 8 women, 7 Kadish stage B, 17 stage C. The planned treatment was: chemotherapy (cisplatin/etoposide) and determine treatment dependent on response in 6 patients, surgery and radiotherapy in 16 patients, and single-modality treatment only (surgery, radiotherapy 1) in 2 patients. Surgery to radiotherapy occurred in 17 patients. With salvage treatment ultimate local control was 79%.
Conclusions
There was a higher local control in those patients who had surgery; abandoning this may carry a higher risk of local failure. The use of response to chemotherapy to determine local treatment remains experimental. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
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