Immunohistochemical study identifying prognostic biomolecular markers in nasopharyngeal carcinoma treated by radiotherapy
Yeon-Joo Kim MD
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea
The first two authors contributed equally to this work.
Search for more papers by this authorHeounjeong Go MD
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
The first two authors contributed equally to this work.
Search for more papers by this authorCorresponding Author
Hong-Gyun Wu MD, PhD
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Korea
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, KoreaSearch for more papers by this authorYoon Kyung Jeon MD, PhD
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
Search for more papers by this authorSuk Won Park MD, PhD
Department of Radiation Oncology, Chung-Ang University College of Medicine, Seoul, Korea
Search for more papers by this authorSeung Hee Lee MS
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Korea
Search for more papers by this authorYeon-Joo Kim MD
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea
The first two authors contributed equally to this work.
Search for more papers by this authorHeounjeong Go MD
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
The first two authors contributed equally to this work.
Search for more papers by this authorCorresponding Author
Hong-Gyun Wu MD, PhD
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Korea
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, KoreaSearch for more papers by this authorYoon Kyung Jeon MD, PhD
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
Search for more papers by this authorSuk Won Park MD, PhD
Department of Radiation Oncology, Chung-Ang University College of Medicine, Seoul, Korea
Search for more papers by this authorSeung Hee Lee MS
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Korea
Search for more papers by this authorAbstract
Background
We evaluated the predictive significance of 14 reported markers using immunohistochemical study in nasopharyngeal carcinoma.
Methods
Immunohistochemical stainings were done in 38 patients for Met, cyclooxygenase-2 (COX-2), nm23-H1, epidermal growth factor receptor (EGFR), p63, early growth response factor 1 (Egr1), chromosome segregation 1-like (CSE1L), cathepsin-D (aspartyl protease), C-erbB2, p53, signal transducers and activators of transcription (STAT3/STAT5), CD138 (Syndecan-1), and LIN28 with the usual methods.
Results
The median follow-up time was 30 months (11–83 months). High Met and CD138 expression were statistically significant negative prognostic factors on survival. The expression of Egr1 had a positive prognostic effect on survival. The combined score of these 3 markers, Met plus CD138 minus Egr1, was a strong prognostic factor. The median survival curve was distinctly separated in accord with this combined score. No prognostic value was revealed in COX-2, nm23-H1, EGFR, p63, CSE1L, cathepsin-D, C-erbB2, p53, STAT3, STAT5, and LIN28.
Conclusions
The combined score of these markers could be used to stratify biomolecular risk groups. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
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