Volume 26, Issue 5 pp. 396-400

Regular Article

Angiogenesis and skin carcinomas with skull base invasion: a case–control study^†

Claudio R. Cernea MD,

Claudio R. Cernea MD

[email protected]

Department of Head and Neck Surgery, University of São Paulo Medical School, São Paulo, Brazil

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Alberto R. Ferraz MD,

Alberto R. Ferraz MD

Department of Head and Neck Surgery, University of São Paulo Medical School, São Paulo, Brazil

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Inês V. de Castro MD,

Inês V. de Castro MD

Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil

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Miriam N. Sotto MD,

Miriam N. Sotto MD

Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil

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Ângela F. Logullo MD,

Ângela F. Logullo MD

Department of Pathology, Federal University of São Paulo, São Paulo, Brazil

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Carlos E. Bacchi MD,

Carlos E. Bacchi MD

Department of Pathology, São Paulo State University, Botucatu, Brazil

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André S. Potenza MD,

André S. Potenza MD

Department of Head and Neck Surgery, University of São Paulo Medical School, São Paulo, Brazil

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Claudio R. Cernea MD,

Claudio R. Cernea MD

[email protected]

Department of Head and Neck Surgery, University of São Paulo Medical School, São Paulo, Brazil

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Alberto R. Ferraz MD,

Alberto R. Ferraz MD

Department of Head and Neck Surgery, University of São Paulo Medical School, São Paulo, Brazil

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Inês V. de Castro MD,

Inês V. de Castro MD

Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil

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Miriam N. Sotto MD,

Miriam N. Sotto MD

Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil

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Ângela F. Logullo MD,

Ângela F. Logullo MD

Department of Pathology, Federal University of São Paulo, São Paulo, Brazil

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Carlos E. Bacchi MD,

Carlos E. Bacchi MD

Department of Pathology, São Paulo State University, Botucatu, Brazil

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André S. Potenza MD,

André S. Potenza MD

Department of Head and Neck Surgery, University of São Paulo Medical School, São Paulo, Brazil

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First published: 27 April 2004

https://doi.org/10.1002/hed.10399

Citations: 8

^†

Presented at the Sixth Research Workshop on the Biology, Prevention and Treatment of Head and Neck Cancer. October 9–13, 2002, McLean, Virginia

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Abstract

Background.

Some skin carcinomas may be very aggressive. Intensity of angiogenesis, measured by intratumoral vessel density using expression of CD34, has been associated with tumor aggressiveness. In this study, the expression of CD34 in basal cell carcinomas ( BCCs) and squamous cell carcinomas (SCCs) with skull base invasion was compared with that in tumors with good outcome.

Methods.

Expression of CD34 was graded as mild, moderate, and intense, in 24 BCCs and 11 SCCs with skull base invasion. The control group included 23 BCCs and 10 SCCs.

Results.

Intense expression of CD34 was noted in 25.00% of BCCs with skull base invasion, compared with 4.35% in the control group (p = .058). Regarding SCCs, intense expression of CD34 was found in 54.55% of aggressive tumors, compared with 10.00% in the control group (p = .133).

Conclusions.

A trend toward denser microvascular angiogenesis was observed in both BCCs and SCCs with skull base invasion compared with less aggressive controls. © 2004 Wiley Periodicals, Inc. Head Neck 26: 396–400, 2004

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Citing Literature

Volume26, Issue5

May 2004

Pages 396-400

Angiogenesis and skin carcinomas with skull base invasion: a case–control study^†

Abstract

Background.

Methods.

Results.

Conclusions.

REFERENCES

Citing Literature

References

Information

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Angiogenesis and skin carcinomas with skull base invasion: a case–control study†

Abstract

Background.

Methods.

Results.

Conclusions.

REFERENCES

Citing Literature

References

Related

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Angiogenesis and skin carcinomas with skull base invasion: a case–control study^†