Volume 27, Issue 5 pp. 290-294

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Phenylphosphinic acid-catalyzed synthesis of 6-unsubstituted dihydropyrimidinones under solvent-free conditions

Heshmatollah Alinezhad,

Corresponding Author

Heshmatollah Alinezhad

[email protected]

Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

Correspondence

Heshmatollah Alinezhad, Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.

E-mail: [email protected].

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Mahmood Tajbakhsh,

Mahmood Tajbakhsh

Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

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Mahboobeh Zare,

Mahboobeh Zare

Department of Basic Science, Faculty of Science and Herbs, Amol University of Special Modern Technologies, Amol, Iran

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Mahboobeh Mousavi,

Mahboobeh Mousavi

Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

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Heshmatollah Alinezhad,

Corresponding Author

Heshmatollah Alinezhad

[email protected]

Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

Correspondence

Heshmatollah Alinezhad, Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.

E-mail: [email protected].

Search for more papers by this author

Mahmood Tajbakhsh,

Mahmood Tajbakhsh

Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

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Mahboobeh Zare,

Mahboobeh Zare

Department of Basic Science, Faculty of Science and Herbs, Amol University of Special Modern Technologies, Amol, Iran

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Mahboobeh Mousavi,

Mahboobeh Mousavi

Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

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First published: 12 August 2016

https://doi.org/10.1002/hc.21327

Citations: 3

Contract grant sponsor: Research Council University of Mazandaran.

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Abstract

Phenylphosphinic acid is found to catalyze the three-component condensation of an aldehyde, enaminone, and urea or thiourea to afford the corresponding 6-unsubstituted dihydropyrimidinones in high to excellent yields. This methodology is simple and fast synthetic route for the preparation of interesting class of heterocycles.

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Phenylphosphinic acid-catalyzed synthesis of 6-unsubstituted dihydropyrimidinones under solvent-free conditions

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Phenylphosphinic acid-catalyzed synthesis of 6-unsubstituted dihydropyrimidinones under solvent-free conditions

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